BIOCHEMISTRY 

　

　

PUBLICATION record

　

Alcaraz, M. J., A. Habib, C. Creminon, A. M. Vicente, M. Lebret, S. Levy-Toledano, and J. Maclouf. 2001. Heme Oxygenase -1 Induced by nitric oxide in RAW 264. 7 macrophages is upregulated by a cyclo-Oxygenase-2 inhibitor(1). Biochimica Biophysica Acta 1526 (1): 13–6.

　

Bolla, M., K. Matrougui, L. Loufrani, J. Maclouf, B. Levy, S. Levy-Toledano, A. Habib, and D. Henrion. 2002. p38 Mitogen-activated protein kinase activation is required for thromboxane-induced contraction in perfused and pressurized Rat messenteric resistance arteries. Journal. Vascular Research 39 (4): 353–60.

　

Brewer, A., G. Nemer, C. Gove, F. Rawlins, N. Nemer, Patient, R. and J. Pizzey. 2002. Widespread expression of an extended peptide sequence of GATA-6 during murine embryogenesis and non-equivalence of RNA and protein expression domains. Mechanism Development 119 Suppl 1:S121–9.

　

Bruneau, B. G.*, G. Nemer, J. P. Schmitt, F. C. Harron, L. Robitaille, D. A. Conner, M. Gessler, M. Nemer, C. E. Seidman, and J. G. Seidman. 2001. A murine model of holt-oram syndrome defines roles of the T-box transcription factor Tbx5 in cardiogenesis and disease. Cell 106 (6): 709–721. (*Co-first author).

　

Capra, V., A. Habib, M. R. Accomazzo, S. Ravasi, S. Citro, S. Levy-Toledano, S. Nicosia, and G. E. Rovati. 2003. Thromboxane prostanoid receptor in human airway smooth muscle cells: A relevant role in proliferation. European Journal Pharmacology 474:149–159.

　

Contreres, J. O., E. Dupuy, B. Job, A. Habib, M. Bryckaert, J. P. Rosa, G. Simoneau, J. M. Herbert, P. Savi, and S. Levy-Toledano. 2003. Effect of clopidogrel administration to healthy volunteers on platelet phosphorylation events triggered by ADP. British Journal of Haematology (120): 633–42.

　

Degraeve, F., M. Bolla, S. Blaie, C. Creminon, I. Quere, P. Boquet, S. Levy-Toledano, J. Bertoglio, and A. Habib. 2001. Modulation of COX-2 expression by statins in human aortic smooth muscle cells. Involvement of geranylgeranylated proteins. Journal Biological Chemistry 276 (50): 46849–55.

　

Dupuy, E., A. Habib, M. Lebret, R. Yang, S. Levy-Toledano, and G. Tobelem. 2003. Thrombin induces angiogenesis and vascular endothelial growth factor expression in human endothelial cells,. Possible relevance of HIF-1a. Journal of Thrombosis and Hemostasis 1:1096–102.

　

El-Bawab, S., J. Usta, P. Roddy, Z. Szulc, A. Bielawska and Y. Hannun. 2002. Substrate specificity of mitochondrial ceramidase. Journal of Lipid Research 43 (1): 141–148.

　

Eligini, S., A. Habib, M. Lebret, C. Creminon, S. Levy-Toledano, and J. Maclouf. 2001. Induction of cyclo-oxygenase-2 in human endothelial cells by SIN-1 in the absence of prostaglandin production. British Journal Pharmacology 133 (7): 1163–1171.

　

Gallet, C., S. Blaie, S. Levy-Toledano, and A. Habib. 2003. Epidermal growth factor receptor transactivation mediates thromboxane A2-dependent extracellular signal-regulated kinase activation in transfected HEK-293 and human aortic smooth muscle cells. Biochemical Journal 371:733–42.

　

Kreydiyyeh, S., and J. Usta. 2002. Diuretic effect and mechanism of action of parsley. Journal of Ethnopharmacology 79 (3): 353–7.

　

Kreydiyyeh, S., J. Usta, K. Kaouk, and R. Al-Sadi. 2001. The mechanism underlying the laxative properties of parsley extract. Phytomedicine 8 (5): 382–8.

　

Li, P. L Genard, J. Tran-Van Nhieu, J-Ao Suarez-Cuenca, A. Mallat, A. Habib, and S. Lotersztajn. 2003. Heme oxygenase-1 is an antifibrogenic in human hepatic myofibroblasts. Gastroenterology 125:460–9.

　

Meune, C., I. Mahe, J. J. Mourad, A. Cohen-Solal, B. Levy, J. P. Kevorkian, G. Jondeau, A. Habib, M. Lebret, A. L. Knellwolf, G. Simoneau, C. Caulin, and J. F. Bergmann. 2003. Aspirin alters arterial function in patients with chronic heart failure treated with ACE inhibitors: A dose-mediated deleterious effect. European Journal of Heart Failure l 5:271–9.

 

Nemer, G., and M. Nemer. 2001. Regulation of heart development and function through combinatorial interactions of transcription factors. Annals of Medicine 33:604–610.

 

. 2002. Cooperative interaction between GATA-5 and NF-ATc regulates endothelial-endocardial differentiation of cardiogenic cells. Development 129:4045–4055.

 

. 2003. Transcriptional activation of BMP-4 and regulation of mammalian organogenesis GATA-4 and GATA-6. Developmental Biology 254:131–148.

　

Nurden, P., C. Poujol, J. Winckler, R. Combrie, N. Pousseau, P. B. Conley, S. Levy-Toledano, A. Habib, and A. T. Nurden. 2003. Immunolocalization of P2Y1 and TPalpha receptors in platelets showed a major pool associated with the membranes of alpha-granules and the open canalicular system. Blood 101:1400–8.

　

Ogretmen, B., J. M. Kraveka, S. Deborah, J. Usta, Y. Hannun, and L. Obeid. 2001. Molecular mechanisms of ceramide – mediated telomerase inhibition in the A549 hunman lung cancer adenocarcinoma cell line. Journal of Biological Chemistry 31:276 (35): 32506–32514.

　

Ogretmen, B., B. J. Pettus, M. J. Rossi, R. Wood, J. Usta, Z. Szulc, A. Bielawska, L. Obeid, and Y. Hannun. 2002. Biochemical mechanisms of the generation of endogenous long chain ceramide in response to exogenous short chain ceramide in the A549 human lung adenocarcinoma cell line: Role for endogenous ceramide in mediating the action of exogenous ceramide. Journal of Biological Chemistry 12;277 (15): 12960–9.

　

Ogretmen, B., D. Schady, J. Usta, R. Wood, J. Krakeva, C. Luberto, H. Birbres, Y. Hannun, and L. Obeid. 2001. Role of ceramide in Mediating the inhibition of telomerase activity in A549 human lung adenocarcinoma Cells. Journal of Biological Chemistry 276 (27): 24901–24910.

　

Ranelletti, F. O., G. Almadori, B. Rocca, G. Ferrandina, G. Ciabattoni, A. Habib, J. Galli, N. Maggiano, M. Gessi, and L. Lauriola. 2001. Prognostic significance of cyclooxygenase-2 in laryngeal squamous cell carcinoma. International Journal Cancer 95 (6): 343–9.

　

Rocca, B., N. Maggiano, A. Habib, G. Petrucci, M. Gessi, A. Fattorossi, L. Lauriola, R. Landolfi, and F. O. Ranelletti. 2002. Distinct expression of cyclooxygenase-1 and -2 in the human thymus. European Journal Immunology 32 (5): 1482–1492.

 

Usta, J., S. El-Bawab, Z. Sculc, Y. Hannun, and A. Bielawska. 2001. Structural requirements of ceramide and sphingosine based inhibitors of mitochondrial ceramidase. Biochemistry 40 (32): 9657–9668.

 

Usta, J., S. Kreydiyyeh, K. Badjakian, and H. Nakkach-Chmaisse. 2002. In vitro effect of eugenol and cinnamaldehyde on membrane potential and respiratory chain complexes in isolated rat liver mitochondria. Food and Chemical Toxicology 40 (7): 935–940.

 

Usta, J., S. Kreydiyyeh, P. Barnaba, Y. Bou-Moghlabey, and H. Nakkach-Chmaisse. 2003. Comparative study of the effect of cinnamon and clove extracts and their main components on different types of ATPases. Human and Experimental Toxicology 22 (7): 355–362.

　

　

　

Abstracts, Conferences, and Proceedings

　

Degraeve, F, M. Bolla, C. Creminon, S. Levy-Toledano, and A. Habib. 2001. Modulation of COX-2 expression by statins in human aortic smooth muscle cells: involvement of geranymgeranylated proteins. International Society of Thrombosis and Haemostasis (ISTH) Meeting, July 6–12, 2001. Paris. Thromb. Haemost. Abstract # OC175.

　

Eligini, S., M. Lebret, A. Habib, C. Creminon, S. Levy-Toledano and J. Maclouf. 2001. Induction of cyclooxygenase-2 in human endothelial cells by SIN-1 in the absence of prostaglandin production. ISTH Meeting, July 6–12, 2001. Thromb. Haemost. Abstract # P1341.

　

Gallet, C., S. Blaie, S. levy-Toledano, and A. Habib. 2002. Mechanisms involved in thromboxane receptor-dependent activation of ERK. Presented at the 12th International Conference on Advances in Prostaglandin, Leukotriene and Other Bioactive Lipid Research. Basic Science and Clinical Application. Istanbul, Turkey, August 25–29, 2002.

　

Habib, A. 2001. The Jacques Maclouf lecture: Thromboxane receptors in human platelets. ISTH Meeting, July 6–12, 2001. Thromb. Haemost. Abstract # SY928.

　

Levy-Toledano, S., C. Gallet, S. Blaie, and A. Habib. 2001. Cross – talk between receptors in platelet activation and smooth muscle cells. Special symposium organized by Servier “Eicosanoids and Isoeicosanoids Receptors and Vascular Biology” held at the ISTH Meeting, Paris, July 6–12, 2001.

　

Nemer, G., and M. Nemer. 2002. Essential role for GATA-5 in endocardial differentiation in TC13 cells. First Canadian Developmental Meeting. Mont-Tremblant, Quesbec, Canada.

　

. 2002. Cooperative interaction between GATA-5 and NF-ATc regulates endothelial-endocardial differentiation of cardiogenic cells. Weinstein Cardiovascular Meeting, Salt Lake City, USA.

　

Nemer, G., L. Robitaille, and M. Nemer. 2002. Developmentally regulated alternative splicing of Tbx5. The American Society for Cell Biology 42nd Annual Meeting, Development and Cardiac Function, San Francisco, CA, December 14–18, 2002.

　

. 2002. Regulation of Tbx5 expression and activity by alternative splicing. T-box International Meeting, Nottingham, England.

　

Nurden, P., C. Poujol, P. Conley, J. Ware, A. Habib. A. Nurden. 2001. Megakaryocytes (MK) and platelets: Trafficking and membrane systems. ISTH Meeting, July 6–12, 2001. Thromb. Haemost. Abstract # SY135.

　

Rocca, B., R. Morosetti, G., A. Habib, G. Ciabattoni, N. Maggiano, F. O. Raneletti, and R. Landolfi. 2002. Selective Induction of COX-1 and Prostanoids During the maturation of myeloid leukemic cells. Presented at the 12th International Conference on Advances in Prostaglandin, Leukotriene and other Bioactive Lipid Research. Basic Science and Clinical Application, Istanbul, Turkey, August, 25–29, 2002.

　

Usta, J., H. Al-Ali, G. Dbaibo, A. Bielawska, Z. Sculz, and Y. Hannun. 2003. The biological effects of urea C6 ceramide an inhibitor of non-lysosomal ceramidase on MCF cells. The American Society for Biochemistry and Molecular Biology Meeting, San Diego, CA, April 11–15, 2003.

　

　

　

Patent

　

Bielawska, A., Y. Hannun, Z. Sculc, and S. E. L. Bawab, and J. Usta. 2002. Inhibitors of Ceramidase and Methods of Use Based Thereon. Application No. 60/304–710.

　

　

　

OTHER ACTIVITIES

　

Habib, A. 2001. The Jacques Maclouf lecture: Human thromboxane A2 receptors in platelets. Presented at the International Society for Thrombosis and Heamostasis (ISTH meeting), Paris, July 6–12, 2001.

　

. 2002. Modulation of Cyclooxygenase-2 by statins. Presented at the 3rd International Meeting on Cyclooxygenase-2 in Regensburg, Germany. Invited speaker by Dr. Bernhard Kramer Department of Internal Medicine, University of Regensburg.

　

. 2002. Modulation of Cyclooxygenase-2 by statins. Presented at the 5th Annual Meeting of the Lebanese Society of Endocrinology, Diabetes and Lipids of Endocrinology, Beirut, Lebanon, May 31–June 2, 2002.

　

　

　

graduate theses and projects

　

Abi-Habib, R. 2002. Kinetics and mechanics of ceramide increases in experimental status epilepticus.