MICROBIOLOGY AND IMMUNOLOGY Publication Record Abdelnoor, A. M. 1999. DNA vaccines. Arab Journal of
Pharmaceutical Sciences.
Abdelnoor, A. M., M. Abdelnoor, W. Heneine, R. Khauli, F.
Kobeissy, S. Mansur, R. Malak, and H. Sharara. 2001. Major histocompatability
complex class I and II antigens frequencies in selected groups of Lebanese.
Transplantation Proceedings. Abdelnoor, A. M., M. Abdelnoor, W. Heneine, F. Kobeissy, S.
Mansur, R. Malak, and H. Sharara. 2000. HLA class I and II frequencies in
selected groups in Lebanon. Lebanese Science Journal. Abdelnoor, A. M., H. Z. Chbaklo, and L. G. Mikael. 1999. The
effect of hemoglobin on some properties of bacterial lipopolysaccharide. Arab
Journal of Pharmaceutical Sciences. Abdelnoor, A. M., Gh. Khaled, Gh. M. Matar, and M. Nabulsi-Khalil.
1999. Assessment of some serum humoral factors in patients with pulmonary
tuberculosis. Journal of Immunology and Immunopathology. Abdelnoor, A. M., Gh. Khaled, Gh. M. Matar, M.
Naboulsi-Khalil, and F. Ramadan. 2000. Evaluation of a serological test for
the diagnosis of tuberculosis using the 38 KDa antigen. Eastern Journal of
Medicine. Abdelnoor, A. M., G. Khaled, F. Ramadan, G. Matar, and M.
Naboulsi. 1999. Assessment of some serum humoral factors in patients with
pulmonary tuberculosis. Journal of Immunology and Immunopharmacology. Haddad, R., D. El-Hassan, A. Araj, A. Hallal, and A. M.
Abdelnoor. 2001. M. Some inflammation-related parameters in patients
following normo- and hypo-thermic cardiopulmonary bypass.
Immunopharmacology and Immunotoxicology. Hadi, U., and Gh. M. Matar. 2000. Bacterial etiology of otitis
media with effusion in a group of Lebanese children. Lebanese Medical
Journal 48 (3):143–146. Hadi, U., S. Serhal, S. Ghosseini, H. Harakeh, and Gh. M.
Matar. 2000. Bacterial etiology of otitis externa in a group of Lebanese
patients. British Medical Journal. Halwani, R., M. Z. Habbal, and A. M. Abdelnoor. 1999. The
antibacterial effect of some constituents of Nigella sativa oil. Arab
Journal of Pharmaceutical Sciences. Harakeh, H., A. M. Abdelnoor, and G. Matar. 1999. Random
amplified polymorphic DNA typing of S. sanguis isolated from human oral
cavity and dental caries. The Global Dental News Journal. Harakeh, H. S., A. M. Abdelnoor, and Gh. M. Matar. 2000.
Amplified polymorphic DNA typing of Streptococcus sanguis isolated
from human oral cavity and dental caries. Global Dental News Journal. Harakeh, H. S., M. Rizk, M. Uwaydah, and Gh. M. Matar. 2000.
Random amplified polymorphic DNA typing of Enterococcus faecalis. Eastern
Journal of Medicine. Khauli, R. B., W. Medawar, A. Berberi, M. Daouk, A. M.
Abdelnoor, M. Uwaydah, P. J.
Dyvasian, T. Lavewell, J. S. Staff, P. Y. Fan, P. Bigwood, and R.
Harland. 2001. Improved primary transplant success rates using a triple
regimen of cyclosporin microemulsion, mycophenolate mofetil and prednisone.
Transplantation Proceedings. Matar, G., W. A. Aboul-Khadoud, M. Fayad, R. Choueiri, M.
Mikati, and A. M. Abdelnoor. 2000. Herpes simplex encephalitis cases with
typical and atypical symptoms confirmed by PCR-amplification of the DNA
polymerase genes. Eastern Medical Journal. Matar, G. M., N. El-Ghossein, and M. Uwaydah. 1999. Relative occurence of an insertion like sequence, in the promotor region of Bla-TEM gene of beta-lactam resistant gram-negative organisms. Revue Medicale Libanaise 11: 10-11. Matar, G. M., H. S. Harakeh, F. Ramlawi, and U. Hadi. 2001. Comparative analysis between Pseudomonas aeruginosa genotypes and severity of symptoms in patients with unilateral or bilateral otitis externa. Current Microbiology 37 (12):4045–4047. Matar, G. M., J. E. Koehler, G. Malcolm, M. A. Lambert-Fair, J. Tappero, and B. Swaminathan. 1999. Identification of Bartonella species directly in clinical specimens by PCR-restriction fragment length polymorphism analysis of a 16S rRNA gene fragment. Journal of Clinical Microbiology 37 (12):4045–4047. Matar, Gh. M., W. Aboulkhoudoud, M. Fayad, R. Choueiri, M.
Mikati, and A. M. Abdelnoor. 2000. Herpes simplex encephalitis cases with
typical and atypical clinical symptoms confirmed by PCR-amplification of the
DNA polymerase gene. Eastern Journal of Medicine. Matar, Gh. M., R. Chahwan, N. Fuleihan, M. Uwaydah, and U.
Hadi. 2001. PCR-based detection, restriction endonuclease analysis and
transcription of ton B gene in H. influenzae and H.
parainfluenzae isolates obtained from children undergoing tonsillectomy.
Clinical Diagnostic Laboratory Immunology 8 (2):221–224. Matar, Gh. M., N. El-Haddad, and M. Uwaydah. 2000. PCR-RFLP
analysis of TEM beta-lactamase gene in gram-negative bacteria with unusual
susceptibility to beta-lactam antibiotics. British Medical Journal. Abstracts, Conferences, and Proceedings Abdelnoor, A. M. May 2000. Human leucocyte antigens (HLA). 18th
International Congress of the Transplantation Society, Rome, Italy.
Abdelnoor, A. M., M. Abdelnoor, W. Heneine, R. Khauli, F.
Kobeissy, S. Mansur, R. Malak, and H. Sharara. June 2000. MHC class I and II
antigen frequencies in selected groups of Lebanese. 7th International
Congress of the Middle East Society for Organ Transplantation, Beirut,
Lebanon. Abdelnoor, A. M., D. El-Hassan, A. Araj, A. Hallal, and R.
Haddad. August 2000. Endotoxin and inflammation after normo- and hypo-thermic
cardiopulmonary bypass. 6th Conference of the International Endotoxin
Society, Paris, France. Abdelnoor, A. M., D. Farhat, and H. El-Nakat. May 2001.
Protection of mice immunized with genomic DNA extracted from various
bacterial species. Federation of Clinical Immunology Societies, Boston,
Massachusetts, USA. Abdelnoor, A. M., F. Kobeissy, and U. Hadi. May 2000. Allergen
specific IgE antibodies, polyclonal IgE levels, and peripheral eosinophil
levels of patients with rhinitis in Lebanon. Immunology 2000, Seattle,
Washington, USA. Abdelnoor, A. M., G. Matar, and L. Kalfayan. May 2000.
Immunization of mice using S. typhimurium DNA vaccines. Immunology
2000, Seattle, Washington, USA. Abdelnoor, A. M., G. M. Matar, and L. Kelfayan. April 2000.
Immunization of mice using S. typhimurium DNA vaccines. Federation of
American Societies for Experimental Biology, Washington, Seattle, USA. El-Hajj, M., U. Hadi, G. Matar, M. Uwaydah, and N. Fuleihan.
November 1999. Characteristics of
pathogens recovered from tonsils and adenoids in a group of Lebanese children
undergoing T&A with or without bilateral myringotomy with insertion of PE
tubes. Congres Franco-Arabe D'ORL et de Chirurgie Cervico Faciale,
Beirut, Lebanon. Hadi, U., H. Harakeh, S. Serhal, and G. M. Matar. November
1999. Characteristics of pathogens encountered in otitis externa in a group
of Lebanese patients. Congres Franco-Arabe D'ORL et de Chirurgie
Cervico-Faciale, Beirut, Lebanon. Hadi, U., F. Kobeissy, and A. M. Abdelnoor. September 2000.
Some immunologic determinants in Lebanese patients with allergic rhinitis.
Nose 2000, Washington DC, USA. Harakeh, H. S., F. Ramlawi, U. Hadi, and G. M. Matar. May
2000. Virulence factors of P.
aeruginosa isolated from patients with otitis externa in relation to
symptoms. American Society for Microbiology, Los Angeles, California, USA. Khauli, R. B., W. Medawar, A. Habbal, A. Berbari, A. Daouk, A.
M. Abdelnoor, M. Uwaydah, P. J.
Dyvasian, T. Lavewell, J. S. Staff, P. Y. Fan, P. Bigwood, and R. Harland.
June 2000. Improved primary transplant success rates using a triple regimen
of cyclosporin microemulsion, mycophenolate mofetil and prednisone. 7th
International Congress of the Middle East Society for Organ Transplantation,
Beirut, Lebanon. Matar, G. M., R. Chahwan, N. Fuleihan, M. Uwaydah, and U. Hadi. May 2001. DNA-based subtypes and antibiotics profiles of H. influenzae and H. parainfluenzae obtained from multiple tonsillar sites per individual in patients undergoing tonsillectomy and adenoidectomy. Middle East Medical Assembly, Beirut, Lebanon.
Matar, G, M., R. Chahwan, N. Fuleihan, M. Uwaydah, H. Harakeh, and U. Hadi. May 2001. Random amplified polymorphic DNA analysis of H. influenzae and H. parainfluenzae isolated from multiple tonsillar sites per individual in patients undergoing tonsillectomy and adenoidectomy. American Society for Microbiology, Orlando, Florida, USA. Matar, G. M., H. S. Harakeh, and U. Hadi. August 1999.
Comparative analysis of random amplified polymorphic DNA subtypes of P.
aeruginosa isolates recovered from patients with otitis externa in
relation to severity of symptoms. Pseudomonas 99: Biotechnology and
Pathogenesis American Society for Microbiology Meeting, Maui, Hawaii, USA. Matar, G. M., H. Harakeh, F. Ramlawi, and U. Hadi. May 2000.
Relationship of P. aeruginosa RAPD type carriers of exotoxin A gene
from patients with otitis externa and symptoms. American Society for
Microbiology Meeting, Los Angeles, California, USA. Matar, G. M., F. Ramlawi, H. Harakeh, and U. Hadi. November 2000. Comparative analysis of P. aeruginosa genotypes recovered from patients with otitis externa and severity of symptoms. The 14th Science Meeting, Beirut, Lebanon.
Matar, G. M., N. Sidani, M. Fayad, and U. Hadi. November 1999. Two-step PCR assay for identification of bacterial etiology of otitis media with effusion in infected Lebanese children. 13th Science Meeting, Beirut, Lebanon. Graduate Theses and Projects Chahwan, R. October 2000. Phenotypic and genotypic
characteristics of Haemophilus isolates obtained from patients
undergoing tonsillectomy and adenoidectomy. Gh. M. Matar. El-Nakat, H. June 2001. Immunization of mice with restriction
enzyme digested and non-digested DNA preparations from Pseudomonas
aeruginosa. A. Abdelnoor. Farhat, D. October 2000. Protective studies and antibody
responses in mice using Peudomonas aeruginosa DNA vaccines. A.
Abdelnoor. Kobeissy, F. June 2000. Some immunological parameters in
patients with rhinitis in Lebanon. A. Abdelnoor. Shrayteh, Z. June 2001. Serum HLA antibody, donor soluble HLA
class I, and circulating immune complex levels in renal allograft recipients.
A. Abdelnoor. Research Projects Bacterial DNA and plasmid DNA vaccines Genomic DNA was extracted from Salmonella typhimurium
and Pseudomonas aeruginosanosa.Virulence factor genes from these two
organisms were amplified by PCR, and amplicons-plasmid DNA recombinants were
prepared. The protective effects in mice of the gemonic DNA and recombinant
DNA against lethal challenge with the organisms are being tested. Abdelnoor,
A. (PL). Some immunological aspects of patients with allergic
rhinitis in Lebanon The purpose of this study is to identify causative
allergens in patients with allergic rhinitis in Lebanon and determine
possible correlations among serum allergen-specific antibody, polyclonal IgE,
IL-4, IL-5 and peripheral eosinophil levels. Abdelnoor, A. (PL), and U. Hadi. Serum HLA antibody, donor-soluble HLA class I and
circulating immune complex levels in renal allograft recipients The study is an attempt to correlate anti-HLA class I
antibody, donor-soluble HLA class I and circulating immune complex levels in
renal allograft recipients with allograft rejection or immune tolerance.
Abdelnoor, A. (PL), R. Khauli, and W. Medawar. Assessment of agents that may have a blocking effect on
the expression of E.coli 0157:H7 verocytotoxin gene The study deals with PCR-based detection, transcription
and possibly translation of verocytotoxin gene of E.coli 0157:H7, and
assessment of the role of certain agents on the blocking expression of the
protein. Matar, G. M. Supported by Lebanese National Council for Research Comparative analysis of virulence factors produced by P.aeruginosa
and severity of symptoms in patients with otitis externa A correlation between production of several virulence
factors by P.aeruginosa from patients having unilateral or bilateral
otitis externa and severity of symptoms was done. Data have shown that
detected virulence factors, including protease, elastase, fibrinolysin,
DNase, coagulase, lipase and lecithinase, were all produced by P.aeruginosa
isolates associated with severe symptoms while a few virulence factors,
mostly protease, elastase, and fibrinolysin, were produced by isolates
associated with mild to moderate symptoms. This indicates that severe
symptoms manifested by patients may be due to the overall production of the
virulence factors. Studies are underway to detect, quantitatively, the levels
of these virulence factors. Matar, Gh. M. Supported by URB Genotypic characteristics of E.coli 0157:H7 and
other pathogenic E.coli obtained from diarrheal stools The project deals with isolation of E.coli isolates
from diarrheal stools, and molecular detection of pathogenic isolates by
multiplex PCR. In addition, genotyping of detected pathogenic isolates within
each category will be carried out by Pulsed-Field Gel Electrophoresis to
determine possible strain variation among isolates. Matar. Gh. M. Completed or in progress at AUB Molecular characteristics of Haemophilus species
in head and neck infections Haemophilus isolates obtained from tonsillar sites
of patients undergoing tonsillectomy and adenoidectomy were identified
phenotypically and subtyped by RAPD analysis. Ton B gene encoding a virulence
factor the ton B protein was detected and analyzed by PCR-RFLP analysis in H.influenzae
and H.parainfluenzae. Ongoing work deals with detection of mRNA
transcripts levels in both Haemophilus species. Matar. G. M. The role of P.aeruginosa exotoxin A in relation
to severity of symptoms in patients with otitis externa The study dealt with PCR-based detection and transcription of P.aeruginosa exotoxin A gene in relation to severity of symptoms. Data have shown that exotoxin A gene is detected and transcribed in all tested isolates of P.aeruginosa, associated with severe and mild to moderate symptoms, in patients with otitis externa. Current studies are underway to detect transcription levels of P.aeruginosa exotoxin A gene and severity of symptoms in these patients. Matar, Gh. M. Supported by URB |
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2001. Plasmid DNA vaccines. Current Drug Targets-Immune, Endocrine and
Metabolic Disorders.