RESEARCH PROJECTS
Evaluation of a serological test for the diagnosis of tuberculosis using the 38kDa antigen Abdel Nour, G. Matar, G. Khaled, M. Nabulsi, F. Ramadan.
Epidemiology of congenital heart disease in Lebanon F. Bitar, M. Mikati, S. Allam. (Supported by LNCSR.)
Targeting of the ceramide pathway by viral proteins Apoptosis is important in many aspects of homeostasis, cancer
development and chemotherapy, and the immune response. One of the central
regulators of the apoptotic response appears to be ceramide, a sphingolipid
breakdown product. Treatment with an inducer of apoptosis, such as tumor
necrosis factor a (TNFa), results in the elevation of endogenous ceramide
that subsequently drives the cell towards apoptosis. Some viruses encode
for proteins that disable this defensive response allowing the virus to
produce more progeny before the eventual demise of the infected cell. We
are studying several viral proteins that have been shown to have antiapoptotic
activities and examining their effects on the ceramide pathway of apoptosis.
Preliminary studies show that some viral proteins act upstream of ceramide
generation by directly or indirectly inhibiting enzymes that result in
ceramide generation. Other viral proteins appear to work downstream of
ceramide by inhibiting effector molecules activated by ceramide. G.
Dbeibo. (Supported by AUB MPP, LNCSR, URB.)
Modulation of the TNFa-induced ceramide pathway by E3 proteins of adenovirus Adenoviruses contain a number of proteins that modulate the
apoptotic response. Specifically, some adenoviral proteins encoded by the
E3 region have been shown to inhibit TNFa-triggered apoptosis. In this
project, we are investigating the effect of E3 proteins on the ceramide
pathway of apoptosis as induced by TNFa. For this purpose, we will establish
culture systems in which some TNFa sensitive cell lines will be infected
with adenovirus mutants having specific or no deletions in the E3 region.
We will determine the effect of adenoviral infection and TNFa, alone or
in combination, on cell death and ceraccumulation. Also, the effects of
adenoviral infection on ceramide-induced apoptosis will be determined by
using exogenous ceramide treatment. The role of the E3 region of adenovirus
will then be determined by comparing the effects of wild type virus with
those of a mutant virus lacking the E3 region. G. Dbeibo. (Supported
by the DTS Fund.)
Ceramide inhibits interleukin-2 induction: mechanisms of action Interleukin-2 (IL-2) provides a signal necessary for T-cell
proliferation and, consequently, immune response activation. Expression
of the IL-2 gene is regulated at a transcriptional level by multiple trans-acting
factors binding to the promoter region of the gene including. Glycosphingolipids
have been shown to be immunosuppressants by inhibiting T-cell proliferation.
In this project, we examine the inhibitory role of ceramide, a sphingolipid
breakdown product, on IL-2 induction. Preliminary results show that ceramide
inhibits IL-2 production by Jurkat leukemic T-cells. The mechanism of this
inhibition appears to be through the prevention of NF-kB activation that
is necessary for IL-2 gene transcription. This activity of ceramide is
specific to protein kinase C mediated NF-kB activation and is not evident
in tumor necrosis factor a-mediated NF-kB activation. These studies give
more insight into the mechanisms of growth suppression by ceramide. G.
Dbeibo. (Supported by Diana Tamari-Sabbagh Foundation and LNCSR.)
Unusual presentations of Herpes encephalitis M. Fayad.
Transverse myelitis in a child following Hepatitis b vaccination M. Fayad.
The effect of developmental interventions in the neonatal intensive care unit M. Fayad, R. Choueiri, K. Yunis, and M. Mikati.
Individualized developmental care in level 3 nursery in a developing country A study of the effects of developmental interventions on the
development of neonates hospitalized in a neonatal intensive care unit.
M.
Fayad, R. Choueiri, K. Yunis, U. Yaktin, N. Mounla and M. Mikati. (Supported
by AUB MPP.)
Determination of causative organisms of chronic otitis media in children using PCR M. Fayad, U. Hadi and G. Matar. (Supported by LNCSR.)
Determination of causative organisms in bacterial meningitis M. Fayad, G. Matar and M. Mikati.
Intravenous gamma globulin in Landau-Kleffner syndrome M. Fayad, M. Mikati. 1995-1996.
The neuroprotective effects of phosphagens M. Mikati. (Supported by AUB-URB and LNCSR.)
The effect of experimental status epilepticus on ceramide levels in the developing brain Kainic Acid (KA) induced Status Epilepticus (SE) has been
shown to cause apoptosis in the adult rat brain. Immature rats younger
than P30, however, are resistant to the effects of SE and do not manifest
neuronal death like mature adult animals do. The mechanisms underlying
those differences are not well understood. The Sphingolipid ceramide has
been demonstrated to participate in the regulation of cell response to
stress and to drive the apoptotic response in many nonneuronal and some
neuronal cell culture models. The potential role of ceramide in producing
neuronal injury post SE has been studied. The goal of this study is, thus,
to investigate whether SE is followed by increases in ceramide levels and
whether there are differences in ceramide levels after SE in different
developmental stages. M. Mikati. (Supported by AUB-URB and LNCSR.)
Potential role of ceramide in status epilepticus related brain injury We have recently demonstrated that Kainic Acid (KA) induced
Status Epilepticus (SE) is associated with increases in levels of the sphingolipid
ceramide in adult and prepubescent rats. The goal of this study is, thus,
to investigate whether the demonstrated increases in ceramide are related
to SE associated neuronal injury. We hope to accomplish this by measuring
levels of ceramide and by performing concomitant apoptosis stains in two
different models of KA induced SE that allow, depending on the experimental
conditions, the tested animals to undergo SE with or without subsequent
cell death and apoptosis. In
addition, we plan to perform a third experiment in which the synthesis
of ceramide is inhibited in animals undergoing KA induced SE in order to
find out whether this can prevent the occurrence of apoptosis. M. Mikati.
(Supported by Masobki Research Fund.)
The efficacy and pharmacokinetics of topiramate in intractable epilepsy in infancy and childhood M. Mikati.
(Supported by Janssen Pharmaceutica.)
The effect of chronic hypoxia on the developing brain Although
the effects of acute hupoxia on the developing brain have been shown to
be age dependent, the effects of chronic hypoxia are much less understood.
Chronic hypoxia represents a common problem in patients with cyanotic congenital
heart disease, but it is not known yet what its consequences really are
and whether those are preventable. We, thus, plan to investigate the hypotheses
that chronic hypoxia starting at birth: (1) results in long term impairment
in memory and learning (as assessed by the Morris Water Maze test), (2)
causes long term behavioral abnormalities (as assessed by the Handling
and Open Field test), (3) causes long term epilepsy, increased seizure
susceptibility and neuronal injury (as assessed by video-tape technique,
fluorthyl test, and histologic technique), and (4) worsens consequences
of superimposed acute hypoxic episodes. The eventual goal of this research
is to understand the mechanisms of brain damage that occur in cyanotic
congenital heart disease, and to subsequently, if appropriate, investigate
the mechanisms and means of prevention of those impairments possibly by
the long term use of neuroprotective agents. M. Mikati, F. Bitar.
(Supported by DTS Fund.)
Investigation of the effects genetic and epidemiologic factors have on the types of epilepsy syndromes and their clinical manifestation in Lebanon M.
Mikati, R. Choueiri and M. Fayad. (Supported by Sanofi Winthrop.)
Epidemiology of childhood epilepsy in Lebanon M.
Mikati and M. Fayad.
Pharmacokinetics
and efficacy of lamotrigine in children and neonates
An
investigation of the efficacy, pharmacokinetics and tolerability of the
new antiepileptic drug lamotrigine in children and neonates with seizures
that failed to respond to more traditional drugs. R. Mikati, M. Fayad
and
K. Yunis. (Supported by URB.)
Organochlorine pesticides in milk and blood of Lebanese women Maternal
milk is collected and analyzed for the presence of organochlorine pesticides
in the Agricultural Research Laboratory in Fanar. The level of organochlorine
pesticides is correlated with the dietary habits of the mothers. S.
Mroueh, C. Dagher, R. Talhouk and C. Hilan. (Supported by AUB MPP.)
Effect of maternal factors on fetal CRP Mroueh
and K. Yunis. (Supported by AUB MPP.)
Hyperoxia-induced apoptosis in the neonatal rat lung The
study aims at characterizing the role of apoptosis in hyperoxia-induced
cell death in the neonate. Neonatal rats are put in a hyperoxic environment
up to 7 days. Lung sections are obtained at multiple time points from hyperoxia-exposed
and control animals. Different parameters are being studied: morphologic
changes of apoptosis through TUNEL assay and DNA gel electrophoresis and
production of ceramide, a mediator of apoptosis and release of BCL2 and
BAX, two modulators of apoptosis. S. Mroueh S, K. Yunis, F. Bitar, M.
Nasr, M. Sabban, G. Dbeibo. (Supported by AUB URB.)
Epidemiology of iron deficiency anemia and of lead poisoning in Lebanon S.
Muawkkit, I. Nuweiyhid, M. Ariss, G. Salem, M. Mikati. (Supported by
LNCSR.)
Prevalence of iron deficiency anemia and lead toxicity among children in Lebanon The
goal of this project is to screen healthy infants to identify the prevalence
of iron deficiency and to correlate it to the dietary habits and nutritional
status of children, then to recommend any necessary changes in the diet
and feeding habits of infants, especially before the age of two years.
S.
Muwakkit, I. Nuwayhid, G. Salem, M. Mikati, S. Alami.
Complete recovery of a severely ischemic limb following neonatal arterial occlusion: Case report and review of literature M.
Nabulsi, A. Farhat, F. Bitar,P. Mouawwad, A. Karam, I. Khalil.
Prevalence of hepatitis B infection markers among children in Lebanon M.
Nabulsi, M. Ramadan, G. Araj, M. Ariss, G. Hajj, H. Shaker, A. Farah.
Humoral immunity in tuberculosis in adult and pediatric patients F.
Ramadan, M. Nabulsi and A. Abdel Nour.
Unrecognized hypoglycemia in the newborn K.
H. Yunis and N. Mounla. (Supported by AUB Medical Practice Plan.)
Acceptance of prenatal diagnosis for genetic disorders in Lebanon L.
Zahed L, M. Nabulsi.
Familial haplotype analysis of b thalassemia mutations L.
Zahed, M. Nabulsi.
Alshaibani, K., Nizammudin, N., Raza, S., Alfurayh, O., Almeshari, K., Qunibi, W., Sanjad, S., University of Wisconsin versus Eurocollins solution for kidney preservation: analysis of clinical outcome. Transplantation Proceedings, 30 (7), 3681-2, 1998. Alshaibani, K., Raza, S., Alfurayh, O., Almeshari, K., Qunibi, W., Alahmadi, I., Alsabban, E., Sanjad, S., The kidney transplant program at King Faisal Specialist Hospital: results of the last 10 years. Transplantation Proceedings, 30 (7), 3103-3105, 1998. Alshaibani, K., Raza, S., Almeshari, K., Alfurayh, O., Alahmadi, I., Alsabban, E., Sanjad, S., Should pediatric kidneys be used in cadaveric renal transplantation . Transplantation Proceedings, 30 (7), 3123-3124, 1998. Atiyeh, B.S., Hashim, H.A., Rubeiz, M.T., Hamdan, A.M., Bitar, F.F., Serhal, H.M., Necrotising infection of the orofacial tissues in neonates (noma neonatorum). Case report. Scandinavian Journal of Plastic Reconstructive Surgery and Hand Surgery, 32 (3), 343-45, 1998. Bakdash, T., Holmes, G., Lombroso, C., Duffy, F., Helmers, S., Thiele, E., Mikati, M.A., Madsen, J., Black, P., Riviello, J., Epilepsy surgery in the younger child. Epilepsia, 39 (suppl.6),1998. Bitar, F.F., Byrum, C.J., Kveselis, D.A., Lawrence, D.A., Smith, F.C., In utero management of hydrops fetalis caused by critical aortic stenosis. American Journal of Perinatology, 1 (7),389-91, 1997. Bitar, F.F, el-Zein, C., Tawil. A., Gharzuddine, W., Obeid, M., Intrapericardial teratoma in an adult: a rare presentation. Medical and Pediatric Oncology, 30(4),249-51, 1998. Bitar, F.F., Kveselis, D.A., Smith, F.C., Byrum, C.J., Quaegebeur, J,M,., Double-outlet right ventricle (tetralogy of Fallot type) associated with anomalous origin of the left coronary artery from the right pulmonary artery: report of successful total repair in a 2-month-Old infant. Pediatric Cardiology, 19 (4), 361-2, 1998. Bitar, F.F., Orm, S.A., Dbeibo, G.S., Obeid, M., Muwakkit, S., Disappearance of patent ductus arteriosus in a child with leukemia receiving chemotherapy. Medical and Pediatric Oncology, 31 (6),558, 1998. Bitar, F., Shbaro, R., Mroueh, S., Yunis, K.A., Obeid, M., Dextrocardia, corrected transposition {I,D,D,} and Kartagener’s syndrome: a unique association. Clinical Cardiology, 21 (4), 298-9, 1998. Bolanos, A.R., Sarkisian, M., Yang, Y., Hori, A., Helmers, S.L., Mikati, M. Tandon, P., Stafstrom, C.E., Holmes, G.L., Comparison of valproate and phenobarbital treatment after status epilepticus in rats. Neurology, 51 (1), 41-48,1998. Carmant, L., Kramer, U., Holmes, G.L., Mikati, M.A., Riviello, J.J., Helmers, S.L., Differential diagnosis of staring spells in children: a video-EEG study. Pediatric Neurology, 14 (3), 199-202,1997. Dagher, S., Talhouk, R., Nasrallah, S., Tannous, R., Mroueh, S., Relationship of dietary habits to DDE residues in milk of nursing mothers in Beirut. Food Additives and Contaminants, 16, 307-312,1999. Dangond, F., Garada, B., Murawski, B.J., Rey-Casserly, C., Holman, B.L., Mikati, M.A., Focal Brain dysfunction in a 41 year old man with familial alternating hemiplegia. European Archives of Psychiatry and Clinical Neurosciences, 247, 35-41,1997. Dbaibo, G.S., Regulation of the stress response by ceramide. Biochemical Society Transactions, 25, 557-561,1997. Dbaibo, G.S. and Hannun, Y.A., Molecule of the Month: Cytokine response modifier A (CrmA): a strategically deployed viral weapon. Clinical Immunology and Immunopathology, 86, 134-140,1998. ———, Ceramide: A central regulator of the cellular response to injury and stress. In Molecular Mechanisms of Signaling and Membrane Transport, K.W.A. Wirtz, ed. Springer-Verlag, 211-223, NATO ASI Series, Vol. H 101. Berlin: Heidelberg, 1997. Dbaibo, G.S., Pushkareva, M.Y., Rachid, R,A,, Alter, N., Smyth, M., Obeid, L.M., and Hannun, Y.A. P53-dependent ceramide response to genotoxic stress. Journal of Clinical Investigation, 102, 329-339, 1998. El-Assaad, W., El-Sabban, M.E., Awaraji, C., Abboushi, N., and Dbaibo, G.S., Distinct sites of action of Bcl-2 and Bcl-xL in the ceramide pathway of apoptosis. Biochemical Journal, 336, 735-741. 1998. Fayad, M., Choueri, R., Mikati, M.A., Landau-Kleffner syndrome: consistent response to repeated IV gamma globulin doses, a case report. Epilepsia, 38, 489-494, 1997. Fayad, M.N., Yamout, B.I. and Mroueh, S.M., Alpha-Interferon in the treatment of subacute sclerosing panencephalitis Journal of Child Neurology, 12 (8), 486-488. 1997. Gamard, C.J., Dbaibo, G.S., Liu, B., Obeid, L.M., and Hannun, Y.A., Selective involvement of ceramide in cytokine-innduced apoptosis. Ceramide inhibits phorbol ester activation of nuclear factor. Journal of Biological Chemistry, 272, 16474-16481, 1997. Hasbini, D.A., Mikati, M.A., Successful lamotrigine monotherapy in absence seizures after failure of valproic acid as well as lamotrigine-valproic acid combination. Search on Epilepsy, 3 (2), 9-11, 1999. Itani, M., Mikati, M.A., Early onset of neonatal pneumopericardium. Lebanese Medical Journal, 46 (3), 165-7,1998. Karet, F.E., Finberg, K.E., Nelson, R.D., Nayir, A., Mocan, H., Sanjad, S.A. et al., Mutations in ATP6B1,the B1 subunit of the H+-ATPase, cause autosomal recessive distal renal tubular acidosis with sensorineural deafness. Nature Genetics, 21, 84-90, 1999. Kramer, U., Carmant, L., Mikati, M.A., Electroencephalographic discharges of temporal lobe seizures in children and young adults. Electroencephalography and Clinical Neurophysiology, 107 (5), 353-60, 1998. Kramer, U., Mikati, M.A., Sue, W.C., Focal features in West syndrome indicating candidacy for surgery. Pediatric Neurology, 16, 213-217, 1997. Kramer, U., Sue, W.C., Mikati. M.A., Hypsarrhythmia, Frequency of variant patterns and correlation with etiology and outcome. Neurology, 48, 197-203, 1997. Matar, G., Fayad, M., Mikati, M.A., A two-step protocol for the identification of the etiology of bacterial meningitis in cerebrospinal fluid by PCR-amplification of the 16S ribosomal RNA gene. Eastern Journal of Medicine, 4 (1), 27-31, 1999. Matar, G., Sidani, N., Fayad, M. and Hadi, U., Two-step PCR-based assay for identification of bacterial etiology of otitis media with effusion in infected Lebanese children. Journal of Clinical Microbiology, 36 (5), 1-4, 1998. Mikati, M.A., Choueiri, R., Khurana, D.S., Riviello, J.J., Helmers, S., Holmes, GLH., Gabapentin in mentally retarded children with refractory partial seizures: An efficacy and tolerability study. Journal of Intellectual Disability Research, 42 (Suppl 1), 57-62, 1998. Mikati, M.A, Fayad, M., Choueri, R., IVIG in Landau-Kleffner syndrome (letter). Pediatric Neurology, 19 (5), 399-400, 1998. Mikati, M.A., Holmes, G.L., Lamotrigine in absence and primary generalized epilepsies. Journal of Child Neurology, 12 (Suppl), S29-S37, 1997. ———, Temporal lobe epilepsy. In The Treatment of Epilepsy, ed. Wyllie, E., 2nd edition, 401-415. Baltimore: Williams and Wilkins, 1997. Mikati, M.A., Werner, S., Gatt, A., Liu, Z., Rahmeh, A., Rachid, R., Stafstrom, C.E., Holmes, G.L., Consequences of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor blockade during status epilepticus in the developing brain. Developmental Brain Research, 113, 139-42, 1999. Nabulsi, M., Araj, G., Farah, A., Khalil, A., Hepatitis C virus antibodies in pregnant Lebanese women. Journal of Obstetrics and Gynecology, 17 (6), 548, 1997. Nabulsi, M., Khalil, A., Farah, A., Araj, G., Prevalence of hepatitis B surface antigen in Lebanese pregnant women. International Journal of Gynecology and Obstetrics, 58,243-244,19. Nabulsi, M., Shararah, N., Khalil, A., Perinatal Enterobius vermicularis infection. International Journal of Gynecology and Obstetrics, 60 (3), 285-286,1998. Perry, S.W., Hamilton, J.A., Tjoelker, L.W., Dbaibo, G., Dzenko, K.A., Epstein, L.G., Hannun Y, Whittaker, J.S., Dewhurst, S., and Gelbard, H.A., Platelet-activating factor receptor activation: An initiator step in HIV-1 neuropathogenesis. Journal of Biological Chemistry, 273, 17660-17664, 1998. Samaha, A., Araj, G., Mroueh, S., Post immunization Hib detection in the CSF of a patient with meningococcal meningitis. Lebanese Medical Journal, 45, 40-42, 1997. Sanjad, S.A., Hereditary and acquired renal tubular disorders—the Saudi experience. Saudi Journal of Kidney Disease and Transplantation, 8 (3), 247-259, 1997. Sanjad, S.A., Abbad, A., Shorafa, S., Management of hyperlipidemia in children with refractory nephrotic syndrome: the effect of statin therapy. Journal of Pediatrics, 130, 470-474, 1997. Sanjad, S.A., Al-Abbad, A., Al-Sabban, E. , Primary hyperoxaluria type 1: an underestimated cause nephrocalcinosis and chronic renal failure in Saudi Arabian children. Annals of Saudi Medicine, 19, (1), 8-11, 1999. Simon, D.B., Bindra, R.S., Nelson-Williams, C., Mansfield, J.A., Mendonca, E., Nayr, A., Rodriguez-Soriano, J., Sanjad, S.A., Taylor, C.M., Pitz, D., Brem, A., Trachtman, H., Richard, G.A. and Lifton, R.P., Mutations in the chloride channel ClC-Kb cause Bartter’s syndrome type III. Nature Genetics, 17,171-178, 1997. Stafstrom, C.E., Tandon, P., Hori, A., Liu, Z., Mikati, M.A., Holmes GL. Acute effects of MK801 on kainic acid-induced seizures in neonatal rats. Epilepsy Research, 26, 335-344, 1997. Yunis,
K., Bitar, F., Hayek, K., Mroueh, S., Mikati, M.A., Transient hypertrophic
cardiomyopathy in the newborn following multiple doses of antenatal corticosteroids.
American
Journal of Perinatology, 16 (1), 17-21, 1999.
ABSTRACTS,
PRESENTATIONS AND PROCEEDINGS
Bitar, F., Obeid, M., Alam, S., Mikati, M.A., Khogali, M., Abdel Jawad, M., Epidemiology of cardiac diseases in Lebanon. Lebanese Medical Journal, 47 (1), 72, 1999. Boulghourjian, C., Khogali, M., Yunis, K.A., Determinants of consanguinity and pregnancy outcome in a developing country. Pediatric Research, 45 (4), Part 2, 1400,1999. Choueiri, R., Fayad, M., Matar, G., Aboulkhoudoud, W., Mikati, M., Three presentations for Herpes simplex encephalitis. Lebanese Medical Journal, 47 (1), 74, 1999. Choueiri, R., Fayad, M., Mikati, M., Disturbed liver function test with lamotrigine, three cases, accepted. 8th International Child Neurology Congress, Lublijana, Slovenia, September, 1998. Choueiri, R., Fayad, M., Mroueh, S., Mikati, M., Methylmalonic acidemia: presentation, diagnosis, treatment and follow up of three cases at AUB-MC. Lebanese Medical Journal, 47 (1), 59, 1999. El Hassan, N., Mehanna, A., Bitar, F., Mroueh, S., Yunis, K.A. Theophylline toxicity in a two months old premature infant on Ranitidine. Pediatrics, 102 (3), 776, 1998. Farhat, E.A., Mroueh, S.M., Araj, G.F., Rotavirus gastroenteritis in a tertiary care medical center in Beirut, Lebanon. Lebanese Medical Journal, 47 (1), 62, 1999. Farhat, F., Mikati, M.A., Dbaibo, G., Asaad, W., Lteif, L., Abu Rialy, S., Comparison of ceramide levels after experimental status epilepticus in prepubescent and adult rats. International Congress of Pediatrics, Amsterdam, August 1998. Farhat, F., Mikati, M.A., Dbaibo, G., Asaad, W., Lteif, L., Comair, Y., Abu Rialy, S., Ceramide levels increase after kainic acid induced status epilepticus. Epilepsia, 39 (suppl. 6), 233, 1998. Francis, E., Mikati, M.A., Abu Rialy, S., Lteif, L., Efficacy of gabapentin in experimental status epilepticus. Epilepsia, 39 (suppl. 6), 234,1998. Kramer, U., Mikati, M.A., The USA Alternating Hemiplegia group: Alternating hemiplegia of childhood-laboratory investigations. Child Neurology Society Meeting, Montreal, Canada, 1998. Mikati, M.A., Abu Rialy, S., Lteif, L., Farhat, F., Kaddoura-Daouk, R., Neuroprotective effects of phosphagens in the kainic acid model. Epilepsia, 39 (suppl. 6), 233-234,1998. Mroueh, S., Rouadi, P., Hamed AbdelBaki, D., Zaytoun, G., Foreign body aspiration: ten-year experience at a tertiary medical care center. Congress on Accident Prevention in Children, Saint Joseph University, Beirut, May 1998. Ramadan, M.A., Yunis, K.A., Mroueh, S.M., Ismail, R., Cortas, N., Habbal, Z., Sensitivity of C-reactive protein (CRP) in predicting neonatal infection, Pediatric Research, 43 (4), Part 2, 1470,1998. Shalak, L.F., Boulghourjian, C.M., Yunis, K.A., Azotemia associated with early postnatal pulse steroid therapy in the very low birth weight infants. Pediatric Research, 43 (4), Part 2,1133, 1998. Shalak, L., Perlman, J., Boulghourjian, C.M., Yunis, K.A., Early postnatal pulse steroid therapy in sick very low birth weight infants is associated with significant azotemia. Pediatrics, 102 (3), 772, 1998. Yunis, K.A., Abou Rialy, S., Ismail, R., Helou, M., Computerized data base in a developing country: results of a pilot study in the Newborn Intensive Care Unit (NICU) and the Special Care Nursery (SCN) in a tertiary care center in Lebanon. XXIV Congress of the Union of Middle Eastern and Mediterranean Pediatric Societies, Nice, France, November 1997. Yunis, K.A., Hayek, P., Mroueh, S., Bitar, F. et. al., Transient neonatal hypertrophic cardiomyopathy and antenatal administration of steroids. Pediatric Research, 41 (4), Part 2, 1117, 1997. Yunis, K.A., Khogali, M., Boulghourjian, C., Nasr, L., Cost of neonatal intensive care unit (NICU) and outcome in a tertiary care center in Lebanon: One year experience. Pediatric Research, 45 (4), Part 2,1529, 1999. ———, Feasibility of a national collaborative neonatal network in Lebanon: one-year report. Pediatric Research, 45 (4), Part 2, 1528,1999. Yunis, K.A., Mroueh, S., Rashid, M., Ismail, R., Ghaziri, G., Cortas, N., Habbal ,Z., Bitar, F., Mikati, M., Cord and Early CRP taken within the first six hours of life. XXIV Congress of the Union of Middle Eastern and Mediterranean Pediatric Societies, Nice, France, November 1997. ———, Early C-Reactive protein as predictor of neonatal morbidity. Pediatric Research, 41, 189A, 1997. Yunis, K.A., Tarif, S., Birjawi, G., Haddad, M., Nouredine, B., Bitar, F., Seoud, M., Haidar, R., Hellerman Streif Syndrome: new associated features. XXIV Congress of the Union of Middle Eastern and Mediterranean Pediatric Societies, Nice, France, November 1997. Yunis,
K.A., Tarif, S., Haidar, R., Berjawi, G., Haddad, M., Nouredine, B., Bitar,
F., Seoud, M., Derkaloustian, V., A new syndrome with skeletal, renal and
skin anomalies, reminiscent of, but distinct from, Hallerman-Streif syndrome.
Pediatric
Research, 43 (4), Part 2, 386, 1998.
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