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Obstetrics and Gynecology



RESERACH REPORTS
 

Effect of Lebanese civil war on sperm characteristics

Sperm count, motility and morphology during and after the Lebanese civil war are compared. A. Abu-Musa. (Supported by AUB URB.)
 
 

Failure of fertilization after intracytoplasmic sperm injection in patient with Kartagner’s syndrome and totally immotile spermatozoa

A case of Kartagner’s syndrome with totally immotile spermatozoa and who failed to fertilize oocytes after intracytoplasmic sperm injection is described. The role of assisted technology in these patients is reviewed and discussed. A. Abu-Musa, A. Hannoun, A. Khabbaz, P. Devroey*. (Supported by AUB URB.)
 
 

Effect of human follicular fluid on sperm survival test

Spermatozoa obtained from fertile men are incubated with Ham’s F-10 only and Ham’s F-10 supplemented with 20% follicular fluid or 20% semen. Sperm motility is recorded every 12 hours for 48 hours. The effect of follicular fluid on conserving sperm motility is evaluated. A. Abu-Musa, A. Hannoun, Z. Massaad, K. Takahashi*, A. Khalil. (Supported by AUB URB.)
 
 

Ovarian reserve in patients with autoimune disease

Ovarian resume assessed by menstrual cycle day 3 FSH is evaluated in patients with autoimune disease and compared to controls. A. Abu-Musa, Z. Melhem, I. Salti. (Supported by AUB URB.)
 
 

Genetic mapping of a maternal locus responsible for familial haydatiform moles

The work is completed and the article is submitted and accepted for publication in Human Molecular Genetics, 1999. Y. Bou Moghlabey, R. Kircheissen, M. Seoud, N. El- Mogharbel, I. Van den Veyver, R. Slim. (Supported by AUB URB.)
 
 

A defective gene in the ovum may explain familial recurrent moles with biparental contribution

The work is completed and the article has been submitted and accepted for publication in Human Genetics, 1999. M. Helwani, M. Seoud, L. Zahed, G. Zaatari, A. Khalil, M. Pembrev, R. Slim. (Supported by AUB URB.)
 
 

Cervical cancer treated with external radiation alone 

The objective of our study is to assess the response and the 5 year disease-free survival (DFS) in 86 patients with cervical cancer treated with external radiation (ER) alone at the American University of Beirut Medical Center, from 1977 until 1992. Results: The mean age of patients was 53.9 ± 13.1 years. The mean dose of ER was 6509 ± 1263 cGy. Mean duration of treatment was 6.3 weeks ± 2.5 weeks. Thirty five percent of patients had stages I and II and 65% had stages III and IV. The 5 patients without early response to ER died within one year of therapy. Twenty six patients were lost to follow up and the remaining 60 patients had a 50%, 5 year DFS. The 41 patients with stage IIIB had five year DFS of 40%. Prior hysterectomy had no impact on prognosis. No major complications were encountered. Conclusion: ER alone for cervical cancer is a reasonable alternative to combination radiotherapy in selected cases. A. Khalil, M. Seoud, F. Mattar, A. Shamseddine, H. Kaspar, K. Bitar. (Supported by AUB URB.) 
 
 

Fertility outcome following surgical treatment of ectopic pregnancy

The objective of this study is to assess the influence of conservative vs radical surgical treatment of EP on the postoperative reproductive performance. The medical records of patients with EP treated between 1978 and 1992 were reviewed. 67% of the remaining 116 patients underwent salpingectomy [group A] and 33% underwent less radical procedures such as salpingostomy and salpingotomy [group B]. Patients in group A were significantly older and of higher parity and more advanced ectopic gestation compared to group B. However, history of infertility and IUD use were similar in both groups. Postoperative pregnancy rate was higher in group B (88%) vs group A (65%). Repeat EP was higher in group B (11%) vs 4% in group A, but this difference was not statistically significant. Salpingectomy, the traditional treatment for tubal pregnancy, has resulted in a significant reduction in fertility without a parallel decrease in the rate of recurrent ectopic gestation. A. Khalil, M. Seoud, J. Sawaya, K. Karam. (Supported by AUB URB.) 
 
 

The microbiology and response to systemic and local therapy of vulvovaginal candidiasis

The research is being completed and the publication is in process. M. Seoud. (Supported by Pfizer.)
 
 

Tamoxifen and endometrial and pelvic pathologies in patients with breast cancer, a prospective study

The work is completed and resulted into 3 articles that were sent for publication; their status is as following:

-Tamoxifen & eye changes (under revision)

-Tamoxifen & ovarian cyst (submitted for publication)
-Tamoxifen & endometrial pathologies (accepted in Gynecology Oncology). M. Seoud. (Supported by AUB URB.)

 
 
 
 

ARTICLES, BOOKS AND REPORTS

Abu-Musa, A., Chahine, R., Aridi, O., Karam, K., Successful pregnancy outcome following Tompkins metroplasty done early in pregnancy: Case report. Human Reproduction, 13 (5), 1387 - 1388, 1998.

Abu-Musa, A., Hannoun, A., Khalil, A., Massaad, Z., Karam, K., Artificial endometrial preparation for oocyte donation using synthetic estrogen and progesterone. Clinical and Experimental Obstetrics and Gynecology, 25, 83 - 85, 1998.

Abu-Musa, A., Seoud, M., Suidan, F., A new technique for control of placental site bleeding. International Journal of Gynecology and Obstetrics, 60, 169-170, 1998.

Awwad, J., Awwad, S., Karam, K., Gonadotropin ovarian stimulation following pituitary desensitization and corticosteroid suppression therapy in women with idiopathic spontaneous premature ovarian failure. Human Reproduction, 13 (249), 241, 1998.

Awwad, J., Sawaya, J., Leykin, L., Isaacson, K., Sayegh, R., Chen, Z., The effects of pure folliclestimulating hormone vs human menopausal gonadotropins on steroidogenesis and folliculogenesis during controlled ovarian hyperstimulation for in vitro fertilization and embryo transfer. Human Reproduction, 13, 197, 136, 1998.

Bou Moghlabey, Y., Kircheisen, R., Seoud, M., El-Mogharbel N., Van den Veyver, I., Slim, R., Genetic mapping of a maternal locus responsible for familial haydatiform moles. Human Molecular Genetics, 8 (4), 667–671, 1999.

Hannoun, A., Abu-Musa, A., Gamete intrafallopian transfer (GIFT) in the treatment of severe male factor infertility. International Journal of Gynecology and Obstetrics, 61 (3), 293-295, 1998.

Hannoun, A., Abu-Musa, A., Awwad, A., Kaspar, H., Khalil, A., Clomiphene citrate challenge test: Cycle to cycle variability of cycle day 10 Follicle Stimulation Hormone Level. Clinical and Experimental Obstetrics and Gynecology, xxv (4), 155-156, 1998.

Hannoun, A., Abu-Musa, A., Kaspar, H., Khalil, A., Intrauterine insemination (IUI): The effect of ovarian stimulation and infertility diagnosis on the pregnancy outcome. Clinical and Experimental Obstetrics and Gynecology, xxv (4), 144-146, 1998.

Hannoun, A., Abu-Musa, A., Khalil, A., Spontaneous pregnancy occurring in a donor oocyte cylce: a case report. Clinical and Experimental Obstetrics and Gynecology, xxv (3), 97-98, 1998.

Hannoun, A., Khalil, A., Karam, K., Elective shirodkar procedures: Prognostic factors and post operative pregnancy outcome. International Journal of Gynecology and Obstetrics, 61 (2), 187-188, 1998.

Kaspar, H.G., Dinh, T., Hannigan, E.V., Flow cytometry in cervical adenocarcinoma. Correlating DNA content analysis with the clinical picture. Journal of Reproductive Medicine, 42 (3), 170-172, 1997.

Kaspar, H.G., Kraemer, B.B., Kraus, F.T., DNA ploidy by image cytometry and karyotype in spontaneous abortion. Human Pathology, 29, 1013-1016, 1998.

Khalil, A., Hormone replacement therapy and risk of breast cancer. Middle East Fertility Society Journal, (2), 111-112, 1997.

———, Transdermal vs. oral replacement therapy. Middle East Fertility Society Journal, (2), 116-117, 1997.

Khalil, A., Azar, G., Kaspar, H., Seoud, M., Ultrasound findings in placenta percreta. Journal of Obstetrics and Gynecology, 17 (3), 280-281, 1997.

Khalil, A., Chammas, M., Kaspar, H., Shamseddine, A., Seoud, M., Endometrial cancer implanting in the laparotomy scar. European Journal of Gynecological Oncology, XIX (4), 415-416, 1998.

Khalil, A., Seoud, M., Jamal, J., Shamseddine, A., Non-simultaneous breast and cervical cancers. European Journal of Gynecology Oncology, 18 (5), 43, 1997.

Khalil, A., Seoud, M., Tannous, R., Usta, I., Shamseddine, A., Successful pregnancy in a patient with Bernard Soulier Syndrome. Clinical and Laboratory Haematology, 20 (2), 125-128, 1998.

Khalil, A., Shammas, M., Shamseddine, A., Seoud, M., Fatal Acute tumor lysis syndrome in vulvar cancer. European Journal of Gynecologic Oncology, 19 (4), 415-6, 1998.

Medawar, W., Seoud, M., Ibrahim, K., Habbal, Z., Kahwaji, S., Khalil, A., The relationship between serum levels of erythropoeitin insulin like growth factor-1 and hematocrit in breast cancer patients receiving non-nephrotic chemotherapy. European Journal of Gynecologic Oncology, 19, 591-3, 1999.

Shamseddine A., Khalil A., Seoud, M., Kahwaji, S., Taher, A., Bizri A.R., Medawar W., The relation between erythropoeitin, hematocrit, and hemoglobin in breast cancer patients on non-nephrotic chemotherapy. European Journal of Gynecologic Oncology, 19, 557-9, 1999.

Usta, I., Chammas, I., Khalil, A., Renal cell carcinoma with hypercalcemia complicating a pregnancy: case report and review of the literature. European Journal of Gynecological Oncology, XIX (6), 584-7, 1998.

Usta, I., Khalil, A., Long term complications and ultrasound findings in retained Dilapan Fragments. Internal Journal of Obstetrics and Gynecology, 1998. 
 
 
 

ABSTRACTS, PRESENTATIONS AND PROCEEDINGS
 

Abu-Musa, A., Hannoun, A., The role of gamete intrafallopian transfer (GIFT) in assisted reproduction. 2nd International Symposium in Human Reproduction, Beirut, Lebanon, 1997.

Abu-Musa, A., Karam, K, Female factor infertility in the Arab World: Value of assisted conception technology. Pan Arab Society of Andrological Sciences, Beirut, Lebanon, 1997 

Awwad, J., Awwad, S., Karam, K., Gonadotropin ovarian stimulation following pituitary desensitization and corticosteroid suppression therapy in women with idiopathic spontaneous premature ovarian failure. The Fourteenth Annual Meeting of the European Society of Human Reproduction and Embryology, Goteberg, Sweden, June 1998. 

Awwad, J., Sawaya, J., Leykin, L., Isaacson, K., Sayegh, R., Chen, Z., The effects of pure follicle stimulating hormone vs. human menopausal gonadotropins on steroidogenesis and folliculogenesis during controlled ovarian hyperstimulation for in vitro fertilization and embryo transfer. The Fourteenth Annual Meeting of the European Society of Human Reproduction and Embryology, Goteberg, Sweden, June 1998.

Hannoun, A., Egg donation. The Third International Symposium on Human Reproduction, Abou Jawdeh Hospital, Beirut, Lebanon, April 1998.

———, Effect of war on the menstrual cycle. The Fourteenth Annual Meeting of the European Society of Human Reproduction and Embryology, Goteborg, Sweden, June 1998.

Kaspar, H., Shammas, M., Khalil, A., Abu-Musa, A., Seoud, M., Karam, K., Placental findings in deliveries with meconium stained amniotic fluid. Acta Obstetrica and Gynecologica Scandinavica, 76 (167, 4), 69, 1997, Copenhagen, Denmark, August 3-8, 1997. 

Khalil, A., Seoud, M., Mattar, F., Kaspar, H., Bitar, K., Nagalakshmi, K., Cervical cancer treated with external radiation alone. Middle East Medical Assembly, Beirut, Lebanon, May 1997.

———, Cervical cancer treated with external radiation alone. FIGO, Denmark, August 1997.

Khalil, A., Seoud, M., Sawaya, J., Karam, K., Fertility outcome following surgical treatment of ectopic pregnancy. FIGO, Denmark, 1997.

Seoud, M., Cancer registries in Lebanon: a sum-up. The Lebanese Society of Medical Oncology, 1st meeting, Tyre, Lebanon, September 5, 1998.

Seoud, M., Khalil, A., Issa, P., Kanj, N., Fahl, M., Shamseddine, A., Short term response of advanced cervical cancer to neoadjuvant chemotherapy:a preliminary report. The Whertheim Operation Centenary Scientific Meeting, Vienna, Austria, September 17-20, 1998.

Seoud, M., Saghir, N., Salem, Z., Shamseddine, A., Awwad, J., Mudawwar, W., Khalil, A., Tamoxifen and ovarian cysts. American Society of Clinical Oncology Meeting, 18 (2341), 606a, Atlanta, Chicago, May 13-18, 1999.

Seoud, M., Shamseddine, A., Saghir, N., Khalil, A., Experience with a local tumor registry: the AUBMC experience. 4th Makassed Medical Congress, Beirut, Lebanon, September 23-26 ,1998. 

———, Gynecologic tumor registry at AUBMC, 1983-1998. Pan Arab Oncology Congress, Cairo, Egypt, April 14-18, 1999.

Saghir N., Shamseddine, A., Tawil, A., Taher, A., Salem, Z., Khalil, A., Seoud, M., Breast cancer at the American University of Beirut Medical Center. First National Conference on Health Issues in The Arab Community, Southfield, Michigan, April 30-May 1, 1999.

Slim, R., Seoud, M., Kircheisen, R., Van den Veyver, I., A familial case of recurrent hydatiform moles with biparental genomic contribution. Society of Gynecologic investigation, 46th Annual Meeting, Atlanta, Georgia, March 10-13, 1999.

Usta, I., Management of preterm labor, tocolytic. Saida, Lebanon, February 1997. 

———, Obstetric follow up of multiple pregnancy. Presented at “Le Reproduction Humane” in 2eme Symposium International de Abou Jaoude Hospital, Beirut, Lebanon, April 1997.

———, Oral contraceptive. MOH Rehabilitation Program, Beirut, Lebanon, March & April 1997. 

———, Non-hormonal contraceptive methods. MOH Rehabilitation Program, Beirut, Lebanon, March & April 1997.

———, Basics in prenatal diagnosis. MOH Rehabilitation Program, Beirut, Lebanon, March and April 1997.

———, Meconium aspiration syndrome. Rassoul Aatham Hospital, Beirut, Lebanon, 1997.

———, Diabetes in pregnancy. Chronic Care Center, Beirut, Lebanon, 1997.

———, Birth under water: swim or sink. Obstetric Grandround, Beirut, Lebanon, 1997.

———, Perinatal infections: CMV and Toxoplasma. Pediatric Grandround, Beirut, Lebanon, 1998.

———, Three dimensional ultrasound. Fourth Obstetrics and Gynecology Congress, Amman, Jordan, September 1998. 

———, Perinatal infections—toxoplasma and varicella. Fourth Obstetrics and Gynecology Congress, Amman, Jordan, September 1998.

———, Three dimensional ultrasound. Obstetric Grandround, Beirut, Lebanon, 1998.

———, Obstetrical antecedents of cerebral palsy and their prevention. XXXXIV Middle Medical Assembly, Beirut, Lebanon, May 1999.

———, Obstetrical antecedents of cerebral palsy and their prevention. American University of Beirut, Beirut, Lebanon, April 1999.
 
 
 

MASTER’S THESES 
 

Tayeh, A., The effect of Indepamide on Monocrotaline-induced pulmonary structural remodeling and right ventricular hypertrophy (1998). H. Kaspar.
 
 
 
 
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Last updated on 9/12/1999