RESEARCH PROJECTS
The mechanism of action of zidovudine and alpha interferon in treating HTLV-I associated adult T-cell leukemia/lymphoma (ATL) We showed that the combination of zidovudine (AZT) and alpha
interferon (IFN)
is a potent treatment of HTLV-I associated ATL, an aggressive T cell malignancy.
We investigated the mechanism of action of AZT and IFN using HTLV-I positive
and negative T cell lines. No major modification was observed except at
supra pharmacological doses. Moreover, these little in vitro effects
were less pronounced in ATL derived cell lines compared to control. This
treatment did not induce any significant modification of the expression
of the apoptosis regulatory proteins bcl-2 and p53. Interestingly no in
vitro cytotoxic effect was observed on fresh leukemic cells derived
from one acute ATL patient at diagnosis despite achievement of in vivo
complete remission using the same therapy. These results suggest that the
therapeutic effect of this combination is not through a direct cytotoxic
effect but suggest in vivo modulation of the viral expression and
the antiviral immunity. A. A. Bazarbachi.
(Supported
by MPP and CEDRE.)
The mechanism of action of Arsenic trioxide in combination with alpha interferon in HTLV-I transformed cells We
have shown that the combination of arsenic trioxide (As) and interferon-a
(IFN)
synergize to induce cell cycle arrest and extensive apoptosis in HTLV-I
transformed cells. We investigated the mechanism of action of this combination
on pathways central to the control of cell proliferation and programmed
cell death (apoptosis). We demonstrate here that the combination of As
and IFN specifically targets the transcription factor NF-kB
pathway an essential pathway of cellular transformation by HTLV-I. This
treatment specifically inhibits the transfer from the cytoplasm to the
nucleus of the NF-kB
subunit p65 concomitant with an increase in the level of IkB-a
protein.
IFN and As treatment did not induce any significant modification of the
expression of the Fas antigen (CD95), bcl-2, p53, IkB-band
NF-kB
subunit p50 proteins. Moreover, this treatment induced apoptosis through
a caspase-dependent as well as a caspase-independent pathways. A.A.
Bazarbachi.
(Supported by MPP, LNCSR, and Terry Fox Research Fund.)
Effect of age and gender on PTH dynamics We
systematically evaluated the impact of age and gender on the Ca-PTH axis
using dynamic stimulation with calcium-citrate infusions in 48 normal healthy
individuals. There was no effect of aging and gender on any of the parameters
characterizing the Ca/PTH axis. Healthy aging does not appear to be accompanied
by alterations in PTH. G. El-Hajj Fuleihan, E. Brown*, S. Haden*, J.
Scott*. (Supported by National Institutes of Health.)
Bone turnover is truly circadian While
an increasing body of evidence demonstrates that bone resorption markers
follow a diurnal rhythm, it is still unclear whether these reflect endogenous
changes or are dictated by external factors. We evaluated the diurnal rhythm
of N-telopeptides cross-links (N-Tx) in 8 healthy white male volunteers.
The first 24 hours spent under baseline conditions were followed by 24-48
hours of constant routine conditions (CR, enforced wakefulness in the strict
semirecumbent position, with the consumption of hourly snacks). For both
the baseline day and the CR, circadian rhythm parameters were estimated
from a one harmonic regression model that was applied to the N-Tx data.
During baseline conditions, N-Tx followed a diurnal rhythm with an average
amplitude of 17.9 nM BCE/mM Cr and a Tmax at 5:45 a.m. This
rhythm was preserved under CR with a slight shift in its average upwards
and an increase in its amplitude to 23.8 nM BCE/mM Cr and a Tmax
at 5:15 a.m. In conclusion, N-Tx levels exhibit a diurnal rhythm that persists
during a CR, thereby confirming that a large component of this rhythm is
an endogenous rhythm. G. El-Hajj Fuleihan, E. Klerman*, C. Czeilser*,
E. Brown*. (Supported by National Institutes of Health.)
Effect of posture on PTH diurnal rhythm The most significant hazards facing astronauts
who embark on space flight missions is the significant loss of skeletal
mass. The mechanism (s) for such losses are unclear. In this project, we
used the -5 head down tilt (constant posture CP, a simulation of microgravity)
to evaluate the impact of weightlessness on mineral and skeletal homeostasis.
During baseline conditions, PTH levels followed a bimodal diurnal rhythm
with an average amplitude of 6 pg/mL. This rhythm was preserved under CP
conditions, albeit with different characteristics, thus confirming its
endogenousnature. During the CP, PTH rhythm was unimodal and had a blunted
amplitude measured at 5 pg/mL with a broad plateau from 6 p.m. to 6 a.m.
G.
El-Hajj Fuleihan, E. Klerman*, C. Czeilser*, E. Brown*. (Supported
by National Institutes of Health.)
Bone mineral density in the US: a national random survey At the present there are no guidelines for BMD reporting.
In this national random survey we evaluated the practice of BMD reporting
in the US, using the listing of densitometry centers registered in the
National Osteoporosis Foundation database. Of the 1200 questionnaires mailed,
22.5% were completed and returned. The returned questionnaires reflected
the geographical distribution of the densitometers in the US. Both spine
and hip BMD were routinely measured in 71% of the centers and were expressed
as T scores by 90% of centers. The WHO working group definition of osteoporosis
was used by 65% of the survey respondents and was used as the sole criterion
to make treatment recommendations by 33% of the respondents. Fracture risk
was not mentioned in 31% of reports. There was geographic variation in
reporting fracture risk and variations among specialties in BMD reporting
and clinical recommendations. National guidelines for the inclusion of
validated and clinically relevant information and recommendations in bone
density reports are needed. G. El-Hajj Fuleihan, J.L. Stock*, G. Saifi,
and
M.R. McClung*.
Calcium content of food in Lebanon: accuracy and reproducibility Osteoporosis is on of the commonest public health problems
of modern medicine. Adequate calcium intake is essential to optimize skeletal
health in childhood, adolescence and maintain it during adulthood. The
National Institute of Health Consensus Panel put forward recommendations
for calcium intake at various age groups. Calcium can be provided through
supplements or through natural food sources, the latter a cheaper and in
some ways more optimal source of calcium as it also provides other essential
nutrients and vitamins. Unfortunately, the calcium content of many food
products in Lebanon is unavailable. Furthermore, it is unclear how accurate
the information provided on the few food items that do carry a label is.
It is therefore difficult at this point to make specific recommendations
on how to optimize an individual’s calcium intake using food products in
Lebanon. The aim of this investigation is to evaluate the accuracy and
reliability of calcium content of commonly used food products in Lebanon
that are enriched in calcium. G. El-Hajj Fuleihan, R. Tannous, M. Abouy-Jaoude.
(Supported by URB.)
Prevalence of vitamin D insufficiency in school children in Beirut: safety and efficacy. Vitamin D is essential for growth and development in children.
Vitamin D deficiency results in rickets and osteomalacia. Evidence supports
that the deleterious effect of subclinical vitamin D deficiency results
in poor bone formation, mostly in adults. There is a positive relationship
between vitamin D intake and peak bone mass with a negative effect of subclinical
vitamin D insufficiency on skeletal development in adolescents. The attainment
of suboptimal bone mass during adolescence may be a major reversible risk
factor for osteoporosis in adulthood. The study objectives are to determine
the prevalence of vitamin D insufficiency in school children in Beirut,
characterize vitamin D insufficiency into deficiency or insufficiency,
develop a predictive model for vitamin D levels in children, and to validate
the biological relevance of vitamin D insufficiency in these children.
G.
El-Hajj Fuleihan, M. Naboulsi, M. Choucair, A. Rouhana. (Supported
by Massabni Fund.)
Breast cancer in Lebanon: experience at the American University of Beirut N. El Saghir, A. Shamseddine, A. Taher, A. Tawil, A. Khalil,
M. Seoud.
Bazarbachi, A., El Sabban, M., Nasr, R., Quignon, F.*, Awaraji, C., Kersual, J.*, Dianoux, L.*, Haidar, J., Hermine, O.*, DeThe, H.*, Arsenic trioxide and interferon-a synergize to induce cell cycle arrest and apoptosis in HTLV-I transformed cells. Blood, 93, 278-283, 1999. Bazarbachi, A., Muakkit, S., Ayas, M.*,Taher, A., Salem, Z., Solh, H.*, Haidar, J., Thiamine responsive myelodysplasia. British Journal of Hematology, 102, 1098-1100, 1998. Bazerbachi, A., Rafael, M.*, Gisselbrecht, C.*, Hermine, O. * Lymphomes HTLV-I: aspects cliniques et traitement. In Lymphomes non hodgkiniens, ed. P. Solal-Celigny , et al, 312-318, 1997. Bazarbachi, A., Soriano, V.*, Pawson, R.*, Vallejo, A.*, Moudgil, T.*, Matutes, E.*, Peries, J.*, Molina, A.*, De The, H.*, Schultz, T.F.*, Catovsky, D.*, Gill, P.S.*, Mycosis Fungoides and Sezary syndrome are not associated with HTLV-I infection: an international study. British Journal of Hematology, 98, 927-933, 1997. El Saghir, N.S., Adib, S., Mufarrij, A., Taher, A., Kahwaji, S., Issa, P., Shamseddine, A.I., Cancer in Lebanon: analysis of 10220 cases from the American University of Beirut Medical Center. Lebanese Medical Journal, 46, 4-11, 1998. El Saghir, N.S., Bizri, A.R., Salem, N.S., Hussami, T., Salem, Z., Shamseddine, A.I., Pressure ulcer accelerated wound healing with local injections of granulocyte macrophage-colony stimulating factor. Journal of Infection, 35, 179-182, 1997. El Saghir, N.S., Salem, Z., Adib, S., Bikhazi, K., Issa, Ph., Breast cancer screening: recommendations and controversies, with reference to screening in Lebanon. Lebanese Medical Journal, 45, 206-211, 1997. Hajj-Ali, R., Uthman, I., Salti, I., Zaatari, G., Haddad, M., Nasr, F.W., Wegener's Granulomatosus and diabetes insipidus. Rheumatology, 38 (7), 684-685, 1999. Hermine, O.*, Bazarbachi, A., Lymphomogénèse virale: HTLV-I. In Lymphomes non hodgkiniens, ed. P. Solal-Celigny et al. , 72-77, 1997. Hermine, O.*, Wattel, E.*, Gessain, A.*, Bazarbachi, A., Adult T Cell leukemia: A review of established and new treatments. BioDrugs, 10, 447-62, 1998. Senécal, J.L.*, Rauch, J.*, Grodzicky, T.*, Raynauld, J.P.*, Uthman, I., Nava, A.*, Guimond, M.*, Raymond, Y., Autoantibodies to human nuclear lamin B1 are strongly associated with lupus anticoagulant antibodies in systemic lupus erythematosus. Arthritis and Rheumatism, 42 (7), 1347-53, 1999. Uthman, I., Arayssi, T., Masri, A.F., Rheumatology training at the American University of Beirut. The Journal of Rheumatology, 26 (3), 753-4, 1999. Uthman, I., Bizri, A.R., Hajj-Ali, R., Haraoui, B.*, Miliary tuberculosis presenting as tenosynovitis in a case of rheumatoid arthritis. The Journal of Infection, 37 (2), 196-8, 1998. Uthman, I., Bizri, A.R., Hajj-Ali, R., Nasr, F.W., Khalil, I., Takayasu’s Arteritis presenting as fever of unknown origin: report of 2 Cases and review of the literature. Seminars in Arthritis and Rheumatism, 28 (4), 280-285, 1999. Uthman, I., Bizri, A.R., Khoury, M., Nasr, F.W., Systemic Lupus Erythematosus following E coli Sepsis in an ederly woman. British Journal of Rheumatology, 36 (7), 822-3, 1997. Uthman, I., Bizri, A.R., Shabb, N., Khury, M., Khalifeh, M., Peritoneal Sarcoidosis: case report and review of the literature. Seminars in Arthritis and Rheumatism, 28 (5), 351-4, 1999. Uthman, I., Kassak, K., Nasr, F., Henoch-Schonlein Purpura in adulthood and childhood. Arthritis and Rheumatism, 41 (8), 1518, 1998. Uthman, I., Kassak, K., Sanjakdar, R., Mendelek, V.*, Masri, A.F., Nasr, F.W., International letter: letter from Lebanon. British Journal of Rheumatology, 36 (7), 806-7, 1997. Uthman, I., Masri, A.F., Kassak, K., Arnaout, S. Angiographic findings of Takayasu’s Arteritis in Lebanon. British Journal of Rheumatology, 37 (9), 1030, 1998. Uthman, I., Nasr, F., Kassak, K., Masri, A.F., Systemic lupus erythematosus in Lebanon. Lupus, 8 (9), 713-715, 1999. Uthman, I., Tabbarah, Z., Gharawi, A.*, Hughes Syndrome associated with
cytomegalovirus infection. Lupus, 8 (9), 775-777, 1999.
ABSTRACTS,
PRESENTATIONS AND PROCEEDINGS
Akel, M, Salti, I.S., Azar, S., Successful treatment of parathyroid cyst using ethanol sclerotherapy. American Journal of Medical Sciences, 317, 50-52, 1999. Arnaout, S., Uthman, I., Takayasu’s Arteritis in Lebanon. Journal of Rheumatology, 26(7): 1634, 1999. Bazarbachi, A., Gessain, A.*, Hermine, O.*, Treatment of HTLV-I associated adult Tcell leukemia/lymphoma with a combination of zidovudine and interferon alpha. VIII International conference on human retrovirology: HTLV. Rio De Janeiro, Brazil, 1997. Bazarbachi, A., El Sabban, M., Nasr, R., Quignon, F.*, Awaraji, C., Kersual, J.*, Dianoux, L.*, Haidar, J., Hermine, O.*, Dethe, H.*, Arsenic trioxide and interferon-a synergize to induce cell cycle arrest and apoptosis in HTLV-I transformed cells. Annual meeting of the American Society of Hematology, Miami, 1998. Blood, 92 (suppl 1), 600a, 1998. Bazarbachi, A., Haidar, J., Salem, Z., Solh, H.*, Ayas, M.*, Thiamine responsive myelodysplasia. Annual meeting of the American Society of Hematology, San Diego, 1997. Blood, 90 (suppl 1), 284b, 1997. Bazarbachi, A., Nasr, R., El-Sabban, M., Awaraji, C., Haidar, J., Hermine, O*., Cell cycle effects of zidovudine and interferon alpha on HTLV-I transformed cell lines and fresh ATL cells. Annual meeting of the American Society of Hematology 1997, San Diego. Blood, 90 (suppl 1), 201b, 1997. Carroll, J.*, Testa, M.A.*, Erat, K.*, LeBoff, M.S.*, El-Hajj Fuleihan, G., Modeling fracture risk using bone density age, and years since menopause. American Journal Preventive Medicine, 13 (6), 447-452, 1997. Dakik, H.A., Farmer, J.A.*, He, Z.X.*, Wendt, J.A.*, Pratt, C.M.*, Verani, MS*, Mikati, I.A.*, Mahmarian, J.J.*, Quantitative adenosine thallium-201 single photon tomography accurately predicts risk following acute myocardial infarction: the results of a prospective trial. Presented at the 46th Annual Scientific Session of the American College of Cardiology. Journal of the American College of Cardiology, 29 (Supplement A), 228A, 1997. Dakik, H.A., Farmer, J.A.*, Kleiman, N.S.*, Fistula between left main, left anterior descending, and pulmonary arteries. Circulation, 97, 2091-2092, 1998. Dakik, H.A., Farmer, J.A.*, Kleiman, N.S.*, He, Z.X.*, Wendt, J.A.*, Pratt, C.M.*, Verani, M.S.*, Mahmarian, J.J.*, A strategy of aggressive anti-ischemic drug therapy versus coronary revascularization in high risk patients after myocardial infarction: results of a prospective, randomized tri. Presented at the 46th Annual Scientific Session of the American College of Cardiology. Journal American College of Cardiology, 29 (Supplement A), 53A, 1997. Dakik, H.A., Farmer, J.A.*, Verani, M.S.*, He, Z.X.*, Wendt, J.A.*, Mahmarian, J.J.*, Prognostic value of adenosine thallium-201 SPECT after acute myocardial infarction: a prospective trial. Presented at the Third International Conference of Nuclear Cardiology. Journal of Nuclear Cardiology, 4 (1, Supplement), S27, 1997. Dakik, H.A., Hannoush, H., Alam, S., Atweh, S., Analysis of referral patterns and predictive accuracy in a new nuclear Cardiology laboratory. Presented at the Fourth International Conference of Nuclear Cardiology. Journal of Nuclear Cardiology, 6, 1 (Supplement I), S72, 1999. Dakik, H.A., Howell, J.F.*, Lawrie, G.M.*, Espada, R.*, Weilbaecher, D.G.*, He, Z.X.*, Mahmarian, J.J.*, Verani, M.S.*, Assessment of myocardial viability with Tc-99m sestamibi tomography before coronary bypass grafting: correlation with histopathology and postoperative improvement in cardiac function. Circulation, 96, 2892-98, 1997. Dakik, H.A., Kleiman, N.S.*, Farmer, J.A.*, He, Z.X.*, Wendt, J.A.*, Pratt, C.M.*, Verani, M.S.*, Mahmarian, J.J.*, Intensive medical therapy versus coronary angioplasty for suppressing myocardial ischemia in survivors of acute myocardial infarction: a prospective randomized pilot study. Circulation, 98, 2017-2023, 1998. Dakik, H.A., Mahmarian, J.J.*, Verani, M.S.*, Utilization of invasive and non-invasive testing in patients with acute coronary syndromes. Relation to in-hospital mortality in a large University–affiliated hospital. 71st Annual Scientific Sessions of the American Heart Association. Circulation, 98, 17 (Supplement I) I-653, 1998. ———, Prognostic value of exercise thallium-201 tomography after thrombolytic therapy. Cardiology Review, 14, 50-54, 1997. Dakik, H.A., Mahmarian, J.J.*, Verani, M.S.*, Farmer, J.*, Zhao, G.*, Marian, A.J.*, Association of Angiotensin-I converting enzyme gene polymorphism with myocardial ischemia and patency of the infarct related artery in patients with acute myocardial infarction. Journal of the American College of Cardiology, 29, 1468-73, 1997. Dakik, H.A., Verani, M.S.*, He, Z.X.*, Mahmarian, J.J.*, Adenosine SPECT to asses anti-ischemic drug therapy vs coronary revascularization following acute myocardial infarction. Presented at the third International conference of nuclear Cardiology. Journal of Nuclear Cardiology, 4 (1,Supplement), S44, 1997. El-Hajj Fuleihan, G., Tissue-specific estrogens--the promise for the future. New England Journal of Medicine, 337, 1686-1687 [Editorial], 1997. El-Hajj Fuleihan, G., Klerman, E.B.*, Brown, E.N.*, Choe, Y.*, Brown, E.M.*, Czeisler, C.A.*, The parathyroid hormone circadian rhythm is truly endogenous. Journal of Clinical Endocrinology and Metabolism, 82, 281-286, 1997. El-Hajj Fuleihan, G., Nabulsi, M., Shoucair, M., Rouhana, A.N., Shahine, C.H., Prevalence of vitamin D insufficiency in school children in Beirut. American Society of Bone and Mineral Research, 1999. El-Hajj Fuleihan, G., Seifter, J.,* Scott, J.*, Brown, E.M.*, Calcium regulated renal calcium handling in healthy men: relationship to sodium handling. Journal of Clinical Endocrinology Metabolism, 83, 2366-2372, 1998. El-Hajj Fuleihan, G., Stock, J.L.*, Saifi, G., McClung, M.R.*, Bone mineral density reporting in the US: a national random survey. American Society of Bone and Mineral Research, 1999. El-Sabban, M., Nasr, R., Quignon, F.*, Hermine, O.*, De-The, H.*, Bazarbachi, A., Induction of cell cycle arrest and apoptosis in HTLV-I transformed cells by a combination of arsenic trioxide and interferon alpha. IX International conference on human retrovirology: HTLV, Kagoshima, Japan, 1999. Journal of AIDS and Human Retrovirology, 20, A29, 1999. El Saghir, N.S., Adib, S., Mufarrij, A., Taher, A., Kahwaji, S., Issa, P., Shamseddine, A.I., Cancer in Lebanon and the Arab world. Prooceedings of The First National Conference on Health Issues in the Arab American Community, Southfield, Michigan, USA, April 1999. El Saghir, N., Shamseddine, A., Taher, A., Tawil, A., Khalil, A., Seoud, M., Breast cancer at the American University of Beirut in Lebanon. Proceedings of the Pan Arab Oncology Spring Meeting, Cairo, Egypt, April 1999. Haidar, J., Daher, R., Mahfouz, R., Bazarbachi, A., Serum FLT-3 ligand: a predictive marker for neutropenia during the course of stem cell mobilization for autologous peripheral stem cell transplantation. Annual meeting of the American Society of Hematology, Miami, 1998. Blood, 92 (suppl 1), 122a, 1998. Hourani, M., Birjawi, Gh., Khoury, N., Bazarbachi, A., Comparison of total body MRI and skeletal series in patients with multiple myeloma. Annual meeting of the American Society of Hematology, Miami, 1998. Blood, 92 (suppl 1), 264b, 1998. Hermine, O.*, Gessain, A.*, Bazarbachi, A., Treatment of HTLV-I associated adult T-cell leukemia/lymphoma with a combination of Zidovudine and alpha interferon. Report of the French experience. IX International conference on human retrovirology: HTLV, Kagoshima, Japan, 1999 (oral communication). Journal of AIDS and Human Retrovirology, 20, A7, 1999. ———, Treatment of HTLV-I associated adult Tcell leukemia/lymphoma with a combination of zidovudine and interferon alpha. Annual meeting of the American Society of Hematology, San Diego, 1997. Blood, 90 (suppl 1), 332a, 1997. Haden, S.T.*, El-Hajj Fuleihan, G., Angell, J.E.*, Cotran, N.M.*, LeBoff, M.S.*, Calcidiol and PTH levels in women attending an Osteoporosis Program. Calcified Tissue International, 64, 275-79, 1999. Haden, S.T.*, Stoll, A.L.*, McCormick, S.*, Scott, J.*, El-Hajj Fuleihan, G., Alterations in parathyroid dynamics in lithium-treated subjects. Journal of Clinical Endocrinology and Metabolism, 82, 844-48, 1997. ———, The effect of lithium on calcium-induced changes in adrenocorticotrophin levels. Journal of Clinical Endocrinology and Metabolism, 84, 198-202, 1998. Hajj-Ali, R., Arayssi, T., Nasr, F., Masri, A.F., Uthman, I., Katerji, R., Nuwairy-Salti, N., HLA typing in Lebanese behcet disease patients. Proceedings of the 62nd Annual meeting of the American College of Rheumatology, San Diego, November 1998. He, Z.X.*, Dakik, H.A., Mahmarian, J.J.*, Verani, M.S.*, Relation between myocardial thallium uptake on stress myocardial tomography and severity of coronary artery stenosis by coronary angiography. Circulation, 8 (Supplement I) I-377, 1998. Hwang, W.S.*, Jafar, A.*, Dakik, H.A., He, Z.X.*, Cwajg, E.*, Mahmarian, J.J.*, Verani, M.S.*, Prognostic value of quantitative stress myocardial SPECT imaging in patients with unstable angina. Journal of the American College of Cardiology, 31(Supplement A), 410A, 1998. Khogali, M., Salti, I., Alam, S., Masri, A., Chronic diseases risk factors and risk reduction with special reference to obesity and NIDDM among middle-aged Lebanese, 30-64 Years Old. Nutrition 97 Conference, Beirut, May 2-4, 1997. Lee, J.R.*, Dakik, H.A., He, Z.X.*, Mahmarian, J.J.*, Verani, M.S.*, Myocardial perfusion and angiographic findings in patients with ST-segment elevation during dobutamine stress perfusion imaging. Circulation, 8 (Supplement I) I-443, 1998. Major, S., Salti, I.S., Masri, A., Van Lerberghe, W.*, Boelart, M.*, Khogali, M., Managing diabetes mellitus in a primary care center. Working toward a change. Lebanese Medical Journal, 46, 182-188, 1998. Medleg, R.*, Azar, S., Baz, P.*, Salti, I., Halaby, G.*, Anterior pituitary dysfunction in Wolfram syndrome. The Endocrine Society 81st Annual Meeting, Abstract P3-657, San Diego, USA, June 12-15, 1999. McClung, M.*, Clemmesen, B.*, Daifotis, A.*, Gilchrist, N.L.*, Eisman, J.*, Weinstein, R.S.*, El-Hajj Fuleihan, G., Reda, C.*, Yates, A.J.*, Ravn, P.,* For the Alendronate Osteoporosis Prevention Study Group. Alendronate prevents postmenopausal osteoporosis. Annals of Internal Medicine, 128, 253-261, 1998. Nava, A., Senécal, J.L., Rauch, J., Guimond, M., Uthman, I., Raynauld, J.P., Grodzicky, T., Raymond, Y., Autoantibodies to human nuclear lamin B1 are strongly associated with lupus anticoagulant antibodies in systemic lupus erythematosus. Journal of Rheumatology, 25 (suppl 52): 66, 1998. Olmos, L.I.*, Dakik, H.A., Gordon, R.*, Dunn, J.K.*, Verani, M.S.*, Quinones, M.D.*, Zoghbi, W.A.*, Long-term prognostic value of exercise echocardiography compared with exercise Tl-201 scintigraphy, electrocardiography and clinical variables in patients evaluated for coronary artery disease. Circulation, 98, 2679-2686, 1998. Porter, L.*, Conlin, P.*, Scott, J.*, Brown, E.M*, El-Hajj Fuleihan, G., Calcium modulation of the renin aldosterone axis. Journal Endocrinology and Investigation, 22, 115-21, 1999. Salti, I.S., The problem of osteoporosis in Lebanon: suggested ideas for a consensus in a developing country. International Meeting on Osteoporosis, Beit Mery, April 16-18,1997. ———, Recent Advances in Insulin Therapy. Symposium sponsored by E. Lilly, Damascus, May 1,1997 and Aleppo, May 4, 1997. ———, Is there a consensus for the management of osteoporosis in Lebanon given at special MSD sponsored Symposium entitled Management of Osteoporosis, at the XXXII Middle East Medical Assembly, May 9,1997. ———, Medullary carcinoma of the thyroid, Third Symposium of the Syrian Endocrine Society, Busra Al-Sham, Syria, May 22-23,1997. ———, Glucose toxicity. Fifth Syrian Diabetes Conference, Aleppo, Syria September 12-14,1997. ———, Hormone Replacement Therapy. Meeting of the Lebanese Cardiology Society, Ehden , Sept 15, 1997. ———, Non-andrological medical disorders associated with male infertility. Second Annual Meeting of the Pan- Arab Society of Andrological Sciences, Beirut, Lebanon, November 7-9, 1997. ———, The epidemiology of NIDDM and in relation to other cardiovascular risk factors in Lebanon. Kuwait Diabetes Association Meeting , Kuwait, November 16-18, 1997. ———, Size of the problem and importance of care at the primary care level. Workshop on: Provision of quality diabetic care at the primary care level ARC, Beirut , Lebanon, July 10, 1998. ———, What should the cardiologists know about diabetes. 4th International Congress of Cardiology and Cardiac Surgery, Kaslik, Lebanon, October 21-24, 1998. ———, Non-menopausal causes of osteoporosis. Symposium on Advances in Osteoporosis, Hammoud Hospital, Sidon, Lebanon, November 28,1998. ———, Up-date on Diabetes Mellitus. The Second AUB Alumni Medical Conference, Amman , Jordan, April 8-10, 1999. ———, Auto-immune Thyroiditis-An Under-diagnosed Disease, The Second AUB Alumni Medical Conference, Amman, Jordan, April 8-10, 1999. ———, Glucocorticoid-induced osteoporosis. The Third Syrian Congress of Rheumatology and Rehabilitation, Damascus, Syria, April 22-24, 1999. ———, Secondary Causes of Bone Loss. The Thirty Fourth Middle East Medical Assembly, Beirut, Lebanon, May 6-9, 1999. Salti, I.S., Khogali, M., Alam, S., Masri, A. The epidemiology of NIDDM and in relation to other cardiovascular risk factors in Lebanon, poster presentation at the 16th International Diabetes Federation Congress, Helsinki, July 20-25, 1997. Diabetologia,1997 40, [Suppl 1] Abstract 810, A207. Salti, I.S., Khogali, M., Alam, S., Nassar, N., Abu Haidar, N., Masri, A., The epidemiology of diabetes mellitus in relation to other cardiovascular risk factors in Lebanon. Eastern Mediterranean Health Journal, 3, 462-471, 1997. ———, Epidemiology of cardiovascular risk factors among adult Lebanese population. Lebanese Technical Reports, Lebanese National Council for Scientific Research, 4, 1-72, 1998. Shamseddine, A., Taher, A., Haidar, J., Nasr, R., Salem, Z., Saghir, N., Shaib, F., Bazarbachi, A., Interferon alpha is an effective therapy for congenital dyserythropoietic anemia type I. Annual meeting of the American Society of Hematology, Miami, 1998. Blood, 92 (suppl 1), 23b, 1998. Uthman, I., Is pregnancy a risk factor of flare up in connective tissue disease. Proceedings of the 25th Congress of the Union of Middle Eastern and Mediterranean Pediatric Societies & 2nd Congress of the Lebanese Pediatric Society, Beiurt, Lebanon, April 1999. Uthman, I., Arnaout, S., Takayasu’s Arteritis in Lebanon. Proceedings of the IXth Mediterranean Congress of Rheumatology, Beirut, Lebanon, 1998. Uthman, I., Arnaout, S., Takayasu’s Arteritis in Lebanon. Proceedings of the Annual Meeting of the Canadian Rheumatology Association, Lake Louise, Alberta, Canada, 1999. Uthman, I., Masri, A.F., Nasr, F., Arayssi, T., Mufarrij, A., Mudawar, W., Systemic Lupus Erythematosus: the AUB-MC experience. Proceedings of the IXth Mediterranean Congress of Rheumatology, Beirut, Lebanon, 1998. Uthman, I., Tabbarah, Z.,: Hughes syndrome associated with cytomegalovirus
infection. Proceedings of the 4th Pan-Arab Rheumatology Cogress,
Amman, Jordan, September 1999.
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