Sinplified approach to egg donation using synthetic estrogen and progestogen Our
preliminary experience with oocyte donating using a simplified approach
is reported. Endometrial preparation using synthetic estrogen and progestogen
instead of the natural preparations was done. The pregnancy rate was similar
to that reported in the literature. A. Abu-Musa.
Effect of follicular on sperm survival test Sperm
survival test is used to evaluate the fertilizing capacity of sperm. Washed
spermatozoa were incubated for 72 hours in Ham’s F-10 medium alone or in
Ham’s F-10 medium lus follicular fluid. Sperm moyility was assessed every
24 hours. There was no difference in sperm survival between the two culture
media, suggesting no beneficial effect of follicular fluid on sperm survival.
A. Abu-Musa.
Assessment of ovarian reserve in patients with autoimmune disease Ovarian
reserve using clomiphene challange test is being evaluated in patients
with autoimmune disease (e.g. Hashimoto’s disease) and compared to normal
subjects. A. Abu-Musa.
Placental pathology in patients with meconium stained amniotic fluid: Correlation with cord pH apgar score and fetal heart activity Fetal
outcome assessed by apgar score and cord pH were correlated with the pathologic
findings of placentas having meconium-stained amniotic fluid. A significant
vascular abnormality was seen in placenta of pregnancies with an adverse
outcome. It is concluded that subacute and chronic meconium discharge is
associated with vascular lesions of the placenta and may predict and adverse
pregnancy outcome. A. Abu-Musa and H. Kaspar.
Brucella during pregnancy Report
of 2 cases and literature review. N. Aswad, G. Ghazeeri, H. Kaspar,
A. Abu-Musa and F. Suidan.
Low transverse vaginal septum occuring in siblings N.
Aswad, A. Khabbaz, A. Khalil and F. Suidan.
Cytotec for induction of labor in full term pregnancy N.
Aswad, M. Makarem, Z. Masaad and K. Karam.
Meyer Rokotasky Causter Hayer Syndrome. Incomplete form N.
Aswad, Z. Masaad, A. Hannoun, A. Abu-Musa and K. Karam.
Retained foreign body intraabdominally presenting as an abdominal tumor N.
Aswad, J. Sawaya, M. El-Hajj, J. Usta, J. and K. Karam.
Cytotec for cervical reopening in first trimester abortion N.
Aswad, I. Usta, J. Usta, Z. Masaad and F. Suidan.
Epidural use of Tramadol in obstetrical anesthesia A
clinical prospective study. In Progress. J. Awwad, G. Azar, A. Baraka
and K. Karam.
Internal podalic version of the malpositioned second twin The
mode of delivery of the non vertex second twin remains very controversial,
though the current trend of practice is in favor of the use of cesarean
delivery. We planned to review our ten year experience at the AUB Medical
Center retrospectively in order to evaluate the usefulness and safety of
internal podalic version followed by vaginal breech extraction in the management
of twin gestations with a malpositioned second member. J. Awwad, G.
Azar, A. Khalil, M. Seoud and J Sawaya*.
Photodynamic endometrial ablation in women with dysfunctional uterine bleeding Dysfunctional
uterine bleeding is a common gynecological complaint of perimenopausal
women and is a major cause of hysterectomy nowadays. Because a hysterectomy
is a major surgical procedure that involves high morbidity and expense,
we are investigating the use of a minimally invasive approach that can
achieve the same final clinical outcome. The technique consists of destroying
the endometrium by using photodynamic therapy in an office setting, precluding
the need for anesthesia. The photosensitizers used in this clinical trial
are Photofrin and Benzoporphyrin derivatives. The light source is an argon
pumped dye laser. J. Awwa, L. Bhatta*, P. Dwyer*, T. Hasan*,
R. Anderson* and I. Schiff*. (Supported by the Harvard Center
for Minimally Invasive Therapy at Harvard University.)
A comparative cross-over study of the use of FSH vs. HMG for ovarian stimulation in an IVF program In
this prospective crossover study, the use of pure follicle stimulating
hormone (FSH) was compared with human menopausal gonadotropins (HMG) for
controlled ovarian hyperstimulation following long gonadotropin-releasing
hormone suppression in an IVF-ET program. The effects of both stimulation
protocols on folliculogenesis, oogenesis, and steroidogenesis during ovarian
stimulation are evaluated. J. Awwad, J. Sawaya* and T. Toth*.
The efficacy of a 12-month course of Synarel on pain relief in patients with endometriosis Endometriosis
is a gynecological disease that affects approximately 10% of women. It
is a significant cause of infertility and pelvic pain. Relief of endometriosis-associated
pelvic pain can be attained by medical treatment. However, this approach
is often associated with recurrence of symptoms. We planned to evaluate
the long-term clinical results in terms of symptom relief and recurrences
in women who received the gonadotropin-releasing hormone agonist Synarel
for as long as 12 months. J. Awwad, T. Toth*, R. Sayegh*,
I. Schiff* and J. Finkelstein*.
Description and characterization of an animal model for endometriosis: the SCID mouse Endometriosis
is a significant cause of infertility and pelvic pain in women. Understanding
of this condition has been limited by the absence of an ideal animal model
for the study of the disease. Human endometrial tissues were implanted
successfully unto the peritoneum of SCID mice. This basic molecular research
aims at characterizing the morphological, histological, biochemical, and
immunological properties of human endometrial implants in SCID mice. J.
Awwad, R. Sayegh*, X. Tao*, T. Hassan* and K.
Isaacson*. (Supported by the Center for Innovative Minimally Invasive
Therapy at The Massachusetts General Hospital.)
An open multicenter study of chronic low dose administration of recombinant follicle stimulating hormone (r-FSH) for anovulation associated with polycystic ovary syndrome One
conventional treatment modality of Polycystic Ovary Syndrome associated
unovulation is by ovarian stimulation using follicle stimulating hormone
(FSH). FSH has been obtained thus far through a complex purification process
from the urine of menopausal women. As a result of a major breakthrough
in biotechnology, recombinant FSH can now be prepared in the laboratory.
This multicenter randomized controlled prospective study was designed to
evaluate the clinical efficacy of recombinant FSH compared with urinary
FSH for ovarian stimulation in women with polycystic ovary syndrome. J.
Awwad, et al. (Supported by Serono.)
Ultrasound findings in pregnancies resulting from consanguinous marriages This
study has been presented in national and regional meeting. The sample of
patients needs to be increased. G. Azar, L. Zahed, P. Sarouphim, A.
Frangieh, A. Khalil and M. Seoud.
Determinants of multiple pregnancy rate in gamete intrafallopian transfer (GIFT) A.
Hannoun.
Elective uterine cervical cerlage procedures: Prognostic factors and post-operative pregnancy outcome A.
Hannoun.
Emergency cervical cerclage procedure: Post-operative pregnancy outcome A.
Hannoun.
Gamete intrafallopian transfer (GIFT) in severe male factor A.
Hannoun.
Effect of war on the menstrual cycle A.
Hannoun.
Intrauterine insemination (IUI): diagnosis vs outcome A.
Hannoun.
Clomiphene citrate challenge test: cycle to cycle variability A.
Hannoun.
Spontaneous pregancy in a donor egg cycle: case report A.
Hannoun.
The role of gamete intrafallopian transfer in patients with severe male infertility A.
Hannoun and A. Abu-Musa.
Uterine cervical cerclage procedures: Prognostic factors and post operative pregnancy outcome Submitted
to the Journal of Reproductive Medicine. A. Hannoun, A. Khalil
and K. Karam.
Hydrometrocolpos in infancy. A misdiagnosed abdominal mass. Submitted to International Journal of Gynecology and Obstetrics. R. Homsi and K. Karam. Neural tube defects. A retrospective analysis in Lebanon, 1975-1987 Submitted
to the Medical Journal of King Abdul Aziz University. R. Homsi
and K. Karam.
Risks of various types of anticoagulation during pregnancy in women with prosthetic heart valves, the AUB experience H.
Kazma, N. Shasha, S. Alam, N. Aswad, K. Karam and M. S. Arnaout.
Successful pregnancy outcome in a patient on chromic hemodialysis: A case report and review of literature Submitted
to Acta Obstetrica and Gynecologica. A. Khalil, N. Aswad,
and G. B. Azar.
Prenatal ultrasound diagnosis of first and second trimester conjoined twins Submitted
to Acta Obstetrica and Gynecologica. A. Khalil, N. Aswad,
J. Sawaya and N. Aswad.
Non-simultaneous breast and cervical cancer Submitted
to Journal of Obstetrics and Gynecology. A. Khalil, M. Seoud,
J. Jamal and K. Karam.
Non-simultaneous breast and cervical cancers In
press with European Journal of Gynecologic Oncology. A. Khalil,
M. Seoud, J. Jamal and A. Shamseddine.
Prevalence of hepatitis B surface antigen among Lebanese pregnant wmen In
press with International Journal of Gynecology and Obstetrics. M.
Nabulsi, A. Khalil, A. Farah and G. Araj.
Narghille smoking in pregnancy: Antenatal and neonatal outcome Prospective
study of narghille vs cigarette and control. Ready to be sent out to either
American Journal of Public Health or American Journal of Epidemiology.
I. Nuweyhed, G. Azar, B. Yammout and M. Kambris.
Ultrasound findings of placenta percreta Case
report and review of the literature. In press with Journal of Obstetrics
and Gynocology. M. Seoud, G. Azar, H. Kaspar and A. Khalil.
Maternal and neonatal morbidity and mortality in the patient with advanced maternal age 400
pregnant patients above age of 40 years are compared to 400 matched controls
in a retrospective analysis. So far 450 charts have been reviewed and the
study is continuing. M. Seoud, G. Azar, A. Khalil, K. Bitar, I. Dabbouseh,
G. Ghaziri and N. Aswad.
Survey of the nutritional status and the need for nutritional supplementation of a representative segment of the Lebanese population. This
study has been completed and awaits publication. M. Seoud, A. Itani
and R. Sultaneh. (Supported by United Pharmaceuticals.)
Study of the microbiology and response to systemic and local therapy of vulvovaginal candidiasis We
have so far enrolled 52 patients and expect to enroll a total of 150 patients.
September 1994-present. M Seoud, A Khalil, F Matar and G Azar.
(Supported by Pfizer.)
Mass screening for tuberculosis in the obstetrical population at AUB Medical Center This
study surveyed over 850 women in the outpatient department and the private
clinic to determine the frequency of positive PPD and active tuberculosis.
Data collection is finished and it awaits publication. M. Seoud, M.
Nabulsi, A-R. Bizri, A. Khalil, G. Azar, N. Aswad and B. Bash.
Laundry Guillain-Barre Srohl Syndrome in pregnancy: use of high-dose intravenous immunoglobulin This
is a case report of the first pregnant patient with Guillain-Barre syndrome
treated with high dose intravenous immunoglobulin. Accepted with revision
in Acta Obstetrica et Gynecologica Scandinavica. M. Seoud, P.
Sarouphim, G. Azar, A. Khalil and R. Khalifeh.
Tamoxifen and endometrial and pelvic pathologies in patients with breast cancer, a prospective study 74 patients were enrolled in this study and we have now closed patient enrolment. We are continuing a follow-up for a total of two years including a thorough gynecological evaluation with a vaginal ultrasound, an endometrial biopsy, a pelvic examination and an ophthalmologic evaluation. This work has been reported at various stages and is expected to finish around June 1998. M. Seoud, A. Shamseddine, A. Khalil, Z. Salem, N. Saghir, K. Bikhazi, N. Bitar, G. Azar and H. Kaspar. (Supported by URB.) Abu-Musa, A., Takahashi, K.* and Kitao, M.*, Effect of serum from fertile and infertile patients with endometriosis on the development of mouse emb. Acta Obstetricia et Gynecologica Scandinvica, 75, 605-607, 1996. Awwad, J., Office endometrial ablation. In Office Hysteroscopy, 14, St Louis: Mosby-Year Book Inc, 140 pp, 1996. Awwad, J., and Isaacson, K.*, Indications and contraindications of laparoscopy. In Operative Laparoscopy and Hysteroscopy, 2, New York: Churchill Livingstone, 5 pp, 1996. ———, The harmonic scalpel: An intraoperative complication. Obstetrics Gynecology, 88 (Suppl), 718-20, 1996. Khalil, A., Azar, G., Hannoun, A., Sawaya, J., Abu-Musa, A. and Karam, K., Reproductive outcome following abdominal metroplasty. International Journal of Gynecology and Obstetrics, 149, 157-160, 1995. Khalil, A., Azar, G., Kaspar, H., Abu-Musa, A., Chararah, I. and Seoud, M., Giant cervical polyp. Journal of Reproductive Medicine 1996; 41(8)619-621. Khalil, A., Khatib, R., Shamseddine, A., Sharara, N. and Seoud, M., Prolonged intake of chlorambucil for ovarian cancer. European Journal of Obstetrics and Gynecology, Gynecolog and Reproductive Biology, 60 (1), 85-6, 1995. Sayegh, R.*, and Awwad, J., Dysfunctional uterine bleeding. In Primary Care of Women, 32. St Louis: Mosby-Year Book Inc., 230 pp, 1995. Sayegh, R.*, Awwad, J., Maxwell, C.*, Lesse, B.* and Isaacson, K.*, Alpha2-macroglobulin production by the human endometrium. Journal of Clinical Endocrinology and Metabolism, 80, 1021-6, 1995. Sayegh, R.*, Tao, X.*, Awwad, J. and Isaacson, K.*, Localization of the expression of complement component C3 in the human endometrium using in situ hybridization. Journal of Clinical Endocrinology and Metabolism, 81, 1641-9, 1996. Seoud, M., El-Kak, F., Khalil, A. and Kaspar, H., Premenarchal ovarian borderline serous tumor: report of a case and review of the literature. Acta Obstetricia et Gynecologica Scandinvica, 75, 1996. Seoud, M., Kaspar, H., Khalil, A., Azar, G., Abu Musa, A. and Kibbi, A.G. Sub-ungual metastatic choriocarcinoma: a case report. Journal of the American Academy of Dermatology, 34, 511-512, 1996. Seoud, M., Khalil, A., Frangieh, A., Zahed, L., Azar, G. and Nuwayri-Salti, N. Recurrent molar pregnancies in a family with extensive intermarriages: Report of a case and review of the Literature. Obstetrics and Gynecology, 86, 692-695, 1995. Toth, T.*, Awwad, J., Muasher, S.*, Veeck, L.* and Jones, H.*, Suppression and flare regimens of gonadotropin-releasing hormone agonist: Use in women with different basal gonadotropin values in an in vitro fertilization program. Journal of Reproductive Medicine, 41, 321-6, 1996. Usta, I.M. and Sibai, B.M., Acute fatty liver of pregnancy. Lebanese Medical Journal, 434 (4), 186, 1995. ———, PIH and Toxemia. In Intensive Care of the Fetus and Nenate, A. Spitzer (ed), 239. St. Louis: Mosby Year Book, 1996. Usta, I.M., Mercer, B.M., Aswad, N.K. and Sibai, B.M., The impact of a policy of amnioinfusion for meconium-stained amniotic fluid. Obstetrics and Gynecology, 85, 237-241, 1995. Usta,
I.M., Mercer, B.M. and Sibai, B.M., Risk factors for meconium aspiration.
Obstetrics and Gynecology, 86 (2), 230, 1995.
ABSTRACTS, PRESENTATIONS AND PROCEEDINGS Abu-Musa, A., and Karam, K., The role of serum toxic factors in the infertility associated with endometriosis. Annual Meeting of Italian/Jordanian Obstetrics and Gynecology, Jordan, 1996. Abu-Musa, A., Takahashi, K.* and Kitao, M.*, Effect of serum from fertile and infertile patients with endometriosis on the development of mouse embryos. Fifth World Congress on Endometriosis, Japan, 1996. Aswad, N., Gynecological morbidity using gynecological clinic records to determine women’s complaints. Report presented at the First Meeting of Maximizing Arab Maternal Health Network, Cairo, Egypt, December 16-18, 1995. Awwad, J., Bhatta, L. *, Almeter, M. *, Dwyer, P. *, Anderson, R. *, Schiff, I. *Photodynamic endometrial ablation of the human endometrium. Twelfth International Congress on Photobiology. Vienna, Austria, 1996. Awwad, J., Sayegh, R. *, Tao, X. *, Hasan, T. *, Isaacson, K. *, An experimental model for endometriosis: The SCID mouse. American Society for Reproductive Medicine. Seattle, USA, 1995. Fertility Sterility, P-315, S236, 1995. Deeb, M., Ghorayeb, F., Aswad, N., Kabakian, T. and Khayyat, R. Gynecological morbidity in Beirut. Report presented at the Arab Regional Population Conference. Organized by the International Union for Scientific Study of Population, Cairo, Egypt, December 8-12, 1996. Deeb, M., Ghorayeb, F., Kabakian, T. and Aswad, N., Gynecologic morbidity in Beirut. Comparison of two sources of data. Conference on Population and Health in the Arab Region, Beirut, May 30-31, 1997. Frangieh, A.Y., Friedman, S.A., Audibet, F., Usta, I. and Sibai, B.M., Maternal outcome in women with eclampsia. American Journal of Obstetrics and Gynecology, 174 (1), 453, Abstr # 528, 1996. Ghorayeb, F., Deeb, M., Kabakian, T. and Aswad, N., Differentials in women’s perceptions and medical diagnoses of reproductive morbidity in Beirut. Report presented at the Arab Regional Population Conference. Organized by the International Union for the Scientific Study of Population, Cairo, Egypt, December 8-12, 1996. Hannoun, A., Criteria for establishing IVF facilities. Sixth International Health and Hospitalization Congress, Beirut, 10-14 Oct, 1995. ———, Intracytoplasmic sperm injection (ICSI). Seventh International Congress of Health and Hospitalization, Beirut, Lebanon, 16-19 October, 1996. ———, GIFT: Where does it stand? Second International Symposium of Human Reproduction, Beirut, Lebanon, April 19, 1997. Kaspar, H., Abu-Musa, A., Khalil, A. and Aswad, N., Meconium-stained amniotic fluid correlation between placental pathology cord PH and apgar score. International Federation of Gynecology and Obstetrics Meeting, August 1997. Khalil, A., Seoud, M., Mattar, F., Kaspar, H., Bitar, K., Nagalakshmi, K. and Issa. P., Cervical cancer treated with external radiation alone: Thirty-Second Middle East Medical Assembly, Beirut, Lebanon, May 11-13, 1997. Khalil, A., Seoud, M., Sawaya, J. and Karam, K., Fertility outcome following surgical treatment of ectopic pregnancy. Thirty-Second Middle East Medical Assembly, Beirut, Lebanon, May 11-13, 1997. Sayegh, R. *, Tao, X. *, Awwad, J., Isaacson, K. *, Localization of the expression of A2M and A2M-R (LRP) in the human endometrium by in situ hybridization. Society for Gynecologic Investigation. Philadelphia, USA, 1996. Seoud, M., Kanj, N., Khalil, A., Shamseddine, A., Fahl, M. and Issa, P., Pulmonary toxicity in high dose intensive Bleomycin combination eoadjuvant chemotherapy in cervical cancer. Eighteenth World Congress on Diseases of the Chest, the Sixty-Second Annual International Scientific Assembly of the American College of Chest Physicians, San Francisco, USA, October 27-31, 1996. Seoud, M., Khalil, A., Frangieh, A., Zahed, L., Azar, G. and Nuwayri-Salti, N., Recurrent molar pregnancies in a family with extensive intermarriages: Report of a case and review of the Literature. Second Middle East Oncology Congress, Beirut, Lebanon, April 20-22, 1995. ———, Recurrent molar pregnancies in a family with extensive intermarriages: Report of a case and review of the Literature. Eighth World Congress on Gestational Trophoblastic Diseases, Seoul, Korea, November 3-6, 1996. Seoud, M., Khalil, A., Shamseddine, A. and Issa, P., Short term response of squamous cell ca of the cervix to neoadjuvant chemotherapy. The ACOG District IV Annual Meeting, Buena Vista, USA, October 19-22, 1996; Thirty-First Middle East Medical Assembly, May 1996. Seoud, M., Shemaseddine, A., Khalil, A., Salem, Z., Saghir, N., Bikhazi, K., Bitar, N., Azar, G. and Kaspar, H., Tamoxifen and gynecologic pathologies: A prospective study. Thirty-Second Middle East Medical Assembly, Beirut, Lebanon, May 11-13, 1997; Second Middle East Oncology Congress, Beirut, Lebanon, May 1-3, 1997; The FIGO, Copenhagen, Denmark, August 3-8, 1997; ACOG District IV Annual Meeting, Norfolk, USA, October 24-28, 1997. Seoud, M., Sultan, R., Itani, A. and Khalil, A., Nutritional survey of Lebanese pregnant women. Lebanese Society of Obstetricians and Gynecologists One Day Symposium, Chronic Care Center, Beirut, Lebanon, January 6, 1996. ———, survey of Lebanese pregnant women. Thirty-First Middle East Medical Assembly, Beirut, Lebanon, May 9-12, 1996.
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