RESEARCH PROJECTS
Clinical trial of Fluconazole in the treatment of onychomycosis This
is an ongoing clinical trial of orally administered Fluconazole in the
treatment of patients with onychomycosis. So far eleven patients have completed
the treatment. The results compare well with other oral antifungals. However,
this trial specifically excludes patients with severe onychomycosis. M.
Matta. (Supported by Pfizer Pharmaceuticals.)
The effect of estrogen on pigment production by melanocytes A
possible role for sex hormones in the pathogenesis of melasma has been
suggested because of its frequent association with pregnancy and oral contraceptives.
Estrogenic hormones are thought to enhance melanogenesis, but the mechanisms
by which they interact with the melanin system are still unclear. The purpose
of this project is to study the effect of sex hormones on melanocyte cell
function and more specifically on the synthesis of melanin, and to determine
whether melanogenesis is stimulated through the activation of protein kinase
C. N. Rubeiz, A-G. Kibbi and S. Zaynoun. (Supported by URB.)
The impact of different pre-treatment regimens on chemical peeling The aim of this project is to look into the effects of various topical agents on a medium depth peel. The topical agents to be studied are: retinoic acid 0.1% cream, ammonium lactate 12%, azaleic acid 20% cream, glycolic acid 15% gel, hydroquinone 4% cream, and hydrocortisone 1% cream. They will be used in various combinations before and after the peel. The peeling agents that will be used are trichloroacetic acid 35% and Jessners solution. The potential results that may be arrived at in this study may help better understanding of the impact of different topical agents (pre- and post-peel) on chemexfoliation. That would allow better preparation of the skin to be peeled in order to shorten the post-peel morbidity, augment the cosmetic outcome and minimise potential risks among which is post-inflammatory hyperpigmentation. S. Salman and A-G. Kibbi. (Supported by AUB Medical Practice Plan.) Hassouna, L., Nabulsi-Khalil, M., Mroueh, S.T., Zaynoun, S., and Kibbi, A-G., Multiple erythematous tender papules and nodules in an 11-month-old male infant. Archives of Dermatology, 132 (12), 1507-1512, 1996. Karam, P., La Roche Posay mineral water. Clinics in Dermatology, 14, 607-610, 1996. Karam, P. and Benedetto, A.*, Syringomas: a new therapeutic approach to an old technique. International Journal of Dermatology, 35 (3), 219-220, 1996. Kfoury-Baz, E., Alami, S.Y., Nassif, R.E., Kibbi, A-G., Rubeiz, N.G., and Hannoush, H.M., Transfusion-associated graft-versus-host disease: a report of three cases in immunocompetent patients in Lebanon. Transfusion, 36 (3), 286-287, 1996. Kibbi, A-G., Hassouna, L. and Rubeiz, N.G., Cutaneous leishmaniasis: an old disease with a new face. Acta Dermato-Venereologica, 76 (2), 171-172, 1996. Mousawi, A. and Kibbi, A-G., Pigmented eccrine poroma: a simulant of nodular melanoma. International Journal of Dermatology, 34 (12), 857-858, 1995. Seoud,
M., Kaspar, H., Khalil, A., Azar, G., Abu-Musa, A. and Kibbi, A-G., Subungual
metastatic choriocarcinoma. Journal of the American Academy of Dermatology,
34 (3), 511-512, 1996.
ABSTRACTS, PRESENTATIONS AND PROCEEDINGS El-Saad Debahy, N., Reflex sympathetic dystrophy. First Dermatology Update Conference, Beirut, Lebanon, 1995. , Topical vitamins and skin rejuvenation. Second Dermatology Update Conference, Beirut, Lebanon, 1996. Hassouna, L., Rubeiz, N., Zaynoun S.T. and Shbaklo, Z., Mycosis fungoides-like drug eruption associated with a calcium channel blocker. Proceedings of the Fifty-Fifth Annual Meeting of the American Academy of Dermatology, 145, San Francisco, California, USA, 1997. Karam, P., Chemical peels: general concepts. First Dermatology Update Conference, Beirut, Lebanon, 1995. , Selenium and the skin. Second Dermatology Update Conference, Beirut, Lebanon, 1996. , Resorcin peel. First Middle-Eastern Congress for Dermatologic Surgery, Kaslik, Lebanon, 1996. Kibbi, A-G., Leprosy: update. First Dermatology Update Conference, Beirut, Lebanon, 1995. , Sexually transmitted diseases: the dermatologists role. Proceedings of the Fourth Asian Dermatological Congress, 54, Dubai, United Arab Emirates, 1996. , Granulomatous dermatitis: from the bedside to the microscope. Proceedings of the Fifth International Symposium of Dermatology and Venereology, Riyadh, Saudi Arabia, 1996. , Cutaneous necrotizing vasculitis: an update. Second Dermatology Update Conference, Beirut, Lebanon, 1996. Kibbi, A-G., Rubeiz, N.G. and Suidan-Kawa, N., Leprosy: a new insight into biblical disease. Proceedings of the Fifth International and Pan-Arab Seminar on Leishmaniasis and other Zoonoses, 11-13, Amman, Jordan, 1995. Malak, J., Dermatology in Lebanon. Second Dermatology Update Conference, Beirut, Lebanon, 1996. Matta, M., Acne: update. First Dermatology Update Conference, Beirut, Lebanon, 1995. , Smoking and the skin. Second Dermatology Update Conference, Beirut, Lebanon, 1996. , Sunblockers. First Middle Eastern Congress for Dermatologic Surgery, Kaslik, Lebanon, 1996. Rubeiz, N., Cutaneous lymphomas other than mycosis fungoides. First Dermatology Update Conference, Beirut, Lebanon, 1995. , Transfusion-associated graft-versus-host disease. Second Dermatology Update Conference, Beirut, Lebanon, 1996. Rubeiz, N. and Aoun, A., Neutrophilic eccrine hidradenitis in the absence of malignancy. Proceedings of the Fifty-Fourth Annual Meeting of the American Academy of Dermatology, Washington, DC, USA, 1996. Rubeiz, N., Tannir, D. and Kibbi, A-G., Sweets syndrome: a review of 27 cases. Proceedings of the Fifty-Fifth Annual Meeting of the American Academy of Dermatology, 146, San Francisco, California, USA, 1997. Salman, S., Approach to wound closure. First Dermatology Update Conference, Beirut, Lebanon, 1995. , Autologous fat transplantation. Second Dermatology Update Conference, Beirut, Lebanon, 1996. , Interesting dermatologic surgery cases from the American University of Beirut Medical Center. Fifth Congress of the Pan Arab League of Dermatologists, Khartoum, Sudan, 1996. , Chemical peels: histological changes. First Middle Eastern Congress for Dermatologic Surgery, Kaslik, Lebanon, 1996. Shbaklo, Z., Leishmaniasis. First Dermatology Update Conference, Beirut, Lebanon, 1995. , Profile of leprosy in Lebanon: epidemiology and clinical presentations. Second Dermatology Update Conference, Beirut, Lebanon, 1996. Zaynoun, S.T., The investigation of photosensitivity. First Dermatology Update Conference, Beirut, Lebanon, 1995. , Clinical differential diagnosis of leukodermas. Second Dermatology Update Conference, Beirut, Lebanon, 1996.
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